aladdin 阿拉丁 S413742 SH-4-54 1456632-40-8 97%

中文名：SH-4-54

英文名：SH-4-54

纯度：10mM in DMSO

货号：S421680

Cas号：1456632-40-8

存储温度：-80℃储存

运输条件：特低温运输

产品介绍：

Information

SH-4-54 is a potentSTATinhibitor withKDof 300 nM and 464 nM for STAT3 and STAT5, respectively.

Targets

STAT3 (Cell-free assay); STAT5 (Cell-free assay) 300 nM(Kd); 464 nM(Kd)

In vitro

SH-4-54 shows unprecedented cytotoxicity in human glioblastoma brain cancer stem cells (BTSCs), while has no toxicity in human fetal astrocytes. In addition, SH-4-54 effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets.

In vivo

In mice orthotopically xenografted with BT73, SH-4-54 (10 mg/kg i.p.) exhibits BBB permeability, potently suppresses glioma tumor growth, and inhibits pSTAT3.

Cell Research(from reference)

Cell lines：BTSC lines 25M, 67EF, 73EF, 84EF and 127EF 

Concentrations：~25 μM 

Incubation Time：72 hours 

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