aladdin 阿拉丁 C413744 CH5138303 959763-06-5 99%

中文名：CH5138303

英文名：CH5138303

英文别名：Butanamide,4-​[[4-​amino-​6-​(5-​chloro-​1H,​3H-​naphtho[1,​8-​cd]​pyran-​6-​yl)​-​1,​3,​5-​triazin-​2-​yl]​thio]​-

纯度：99%

货号：C413744

包装：1mg、5mg

Cas号：959763-06-5

存储温度：-20°C储存

产品介绍：

Information

CH5138303 CH5138303 is an orally available Hsp90 inhibitor with K d of 0.48 nM.

Targets

HSP90α (Cell-free assay) 0.48 nM(Kd)

In vitro

CH5138303 shows high affinity to Hsp90αand potent cell growth inhibitory activity against an HCT116 colorectal cancer cell line and an NCI-N87 gastric cancer cell line with IC50 of 98 nM and 66 nM, respectively. [1] Besides, CH5138303 also demonstrates liver microsomal stability.

In vivo

CH5138303 (50 mg/kg p.o.) displays high oral bioavailability in mice and produces potent antitumor efficacy in a human NCI-N87 gastric cancer xenograft model.

Cell Research(from reference)

Cell lines：HCT116 and NCI-N87 cell lines 

Concentrations：~10 μM 

Incubation Time：4 days 

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