aladdin 阿拉丁 O413758 Osilodrostat (LCI699) 928134-65-0 99%

中文名：Osilodrostat (LCI699)

英文名：Osilodrostat (LCI699)

纯度：Moligand™，≥99%

货号：O413758

Cas号：928134-65-0

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Osilodrostat (LCI699) LCI699(Osilodrostat) is a potent inhibitor of 11β-hydroxylase (CYP11B) , an enzyme catalyzing the final step of cortisol synthesis.

Targets

11β-hydroxylase 2.5 nM

In vitro

LCI699 also inhibits aldosterone synthase (CYP11B2) other than CYP11B1.

In vivo

LCI699 is a potent inhibitor of 11β-hydroxylase (CYP11B1), the enzyme that catalyzes the final step of cortisol synthesis, and has a half-life of ∼4 hours. It decreases blood pressure (BP) in patients with essential hypertension and primary aldosteronism. Treatment with LCI699 is well tolerated, it is demonstrated efficacy with a satisfactory safety and tolerability profile in the proof-of-concept study in Cushing\'s disease. The administration of LCI699, up to 1.0 mg BID, effectively and safely inhibits aldosterone synthase in patients with primary aldosteronism.

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