aladdin 阿拉丁 I413832 Iadademstat (ORY-1001) 2HCl 1431326-61-2 98%

中文名：Iadademstat (ORY-1001) 2HCl

英文名：Iadademstat (ORY-1001) 2HCl

纯度：≥98%

货号：I413832

Cas号：1431326-61-2

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Iadademstat (ORY-1001) 2HCl ORY-1001 (RG-6016) 2HCl is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor with IC50 of <20 nM, with high selectivity against related FAD dependent aminoxidases. Phase 1.

Targets

LSD1 20 nM

In vitro

In THP-1 (MLL-AF9) cells, ORY-1001 results in a time/dose dependent me2H3K4 accumulation at KDM1A target genes and concomitant induction of differentiation markers. ORY-1001 also induces apoptosis in THP-1 and inhibits proliferation and colony formation of MV(4;11) (MLL-AF4) cells.

In vivo

In rodent MV(4;11) xenografts, ORY-1001 (<0.020mg/kg, p.o.) leads to significantly reduced tumor growth.

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