aladdin 阿拉丁 P413944 PF-06447475 1527473-33-1 99%

中文名：PF-06447475

英文名：PF-06447475

纯度：Moligand™，≥99%

货号：P413944

Cas号：1527473-33-1

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

PF-06447475 PF-06447475 is a potent, selective, and brain penetrant LRRK2 kinase inhibitor with IC50 of 3 nM.

Targets

LRRK2 (Cell-free assay); G2019S LRRK2 (Cell-free assay) 3nM; 11nM

In vitro

In the macrophage cell line Raw264.7, PF-06447475 inhibits endogenous LRRK2 kinase activity with IC50 of <10 nM. In astrocytes, PF-06447475 rescues LRRK2 mutation-induced defects in lysosomal morphology and function.

In vivo

In G2019S BAC-transgenic mice, PF-06447475 (100 mg/kg, p.o.) inhibits pS935 and pS1292 phosphorylation of LRRK2 with IC50 of 103 nM and 21 nM, respectively. In G2019S-LRRK2 rats, PF-06447475 (30 mg/kg, p.o.) blocks α-synuclein-induced dopaminergic neurodegeneration and attenuates neuroinflammation associated with G2019S-LRRK2 expression.

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