aladdin 阿拉丁 M413920 MS049 dihydrochloride 2095432-59-8 99%

中文名：MS049 dihydrochloride

英文名：MS049 dihydrochloride

纯度：≥99%

货号：M413920

Cas号：2095432-59-8

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

MS049 MS049 is a potent and selective inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively.

Targets

PRMT4 (Cell-free assay); PRMT6 (Cell-free assay) 34 nM; 43 nM

In vitro

MS049 does not inhibit any of the methyltransferases at 50 μM or demethylases at 10 μM and does not display appreciable binding to any of the methyllysine/methylarginine reader proteins using the DSF assay at 200 μM. MS049 demonstrated excellent selectivity over a broad range of epigenetic and nonepigenetic targets. In cellular assays, MS049 potently inhibits the methyltransferase activity of PRMT4 and PRMT6 and reduces levels of Med12me2a and H3R2me2a in HEK293 cells.

Cell Research(from reference)

Cell lines：HEK293 cells 

Concentrations：0, 1, 10, and 50 μM 

Incubation Time：96 h 

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