aladdin 阿拉丁 M413840 MI-136 1628316-74-4 ≥98%

中文名：MI-136

英文名：MI-136

纯度：≥98%

货号：M413840

Cas号：1628316-74-4

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

MI-136 MI-136 can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes.

Targets

Menin-MLL interaction

In vitro

MI-136, a variant of a previously described inhibitor that can specifically inhibit the menin-MLL interaction. AR positive cell lines such as VCaP, LNCaP and 22RV1 are sensitive to MI-136. Treatment with MI-136 also inhibits the expression of genes that are bound to ASH2L after AR stimulation. Treatment with MI-136 induces apoptosis of VCaP cells as evidenced by PARP (cPARP) cleavage and blocks DHT-induced cell proliferation in AR-dependent cell lines (LNCaP and VCaP). The effect of MI-136 on cell proliferation is similar to MDV-3100, a second-generation FDA-approved anti-androgen for patients with refractory prostate cancer.

In vivo

Treatment of VCaP tumor-bearing mice with MI-136 (40mg/kg) leads to a modest but significant reduction in tumor volume with no effect on mouse body weight.

Cell Research(from reference)

Cell lines：VCaP cells 

Concentrations：5 μM 

Incubation Time：48 h 

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