aladdin 阿拉丁 C414475 CB-103 218457-67-1 98%

中文名：CB-103

英文名：CB-103

纯度：Moligand™，≥98%

货号：C414475

Cas号：218457-67-1

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

CB-103 CB-103 is an orally active inhibitor of the Notch transcription activation complex. CB-103 produces Notch loss-of-function phenotypes in flies and mice and inhibits the growth of human breast cancer and leukemia xenografts.

Targets

Notch

In vitro

CB-103 inhibits growth of Notch-addicted human T cell acute lymphoblastic leukemia cell lines through modulation of the Notch transcription complex.

In vivo

CB-103 function in vivo recapitulates genetic notch loss-of-function phenotypes without causing gut toxicity. CB-103 blocks tumor growth of GSI-resistant cancers.

Cell Research(from reference)

Cell lines：marrow mesenchymal stroma cells (MSCs), RPMI-8402 cells 

Concentrations：10 nM to 25 μM, 1 μM 

Incubation Time：3 days, 1 h, 4 h, 24 h 

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