aladdin 阿拉丁 I414423 9-ING-41 1034895-42-5 98%

中文名：9-ING-41

英文名：9-ING-41

纯度：Moligand™，≥98%

货号：I414423

Cas号：1034895-42-5

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

9-ing-41 9-ING-41 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.

Targets

GSK-3

In vitro

9-ING-41, a clinically relevant small molecule GSK-3β inhibitor with broad spectrum pre-clinical antitumor activity, suppresses the growth of neuroblastoma cells. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.

In vivo

9-ING-41 has single-agent antitumor activity in a mouse model of MCL. Mouse xenograft studies shows that the combination of clinically relevant doses of CPT-11 and 9-ING-41 lead to greater antitumor effect than is observed with either agent alone.

Cell Research(from reference)

Cell lines：Neuroblastoma cell lines SK-N-DZ, SK-N-BE 

Concentrations：0.1 μM–1 μM 

Incubation Time：48 h 

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