aladdin 阿拉丁 G414090 GSK'963 2049868-46-2 98%

中文名：GSK'963

英文名：GSK'963

纯度：Moligand™，≥98%

货号：G414090

Cas号：2049868-46-2

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

GSK'963 GSK'963 is a chiral small-molecule inhibitor of RIP1 kinase (RIPK1) with an IC50 of 29 nM in FP binding assays. It is >10 000-fold selective for RIP1 over 339 other kinases.

Targets

RIP1 kinase (Cell-free assay) 29 nM

In vitro

GSK\'963 inhibits RIP1-dependent cell death with an IC50 of between 1 and 4\u2009nM in human and murine cells.

In vivo

GSK\'963 is a potent inhibitor of a TNF+zVAD-mediated lethal shock. At 2\u2009mg/kg, GSK\'963 would maintain blood concentrations above the concentration required for 90% inhibition of RIP1 activity for an extended period of time compared with Nec-1.

Cell Research(from reference)

Cell lines：BMDM 

Concentrations：100\u2009nM 

Incubation Time：30 min 

查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/G414090.html