aladdin 阿拉丁 H157172 4-羟基喹唑啉 491-36-1 ≥98.0%(HPLC)

中文名：4-羟基喹唑啉

英文名：4-Hydroxyquinazoline

应用：

纯度：≥98%(HPLC)

货号：H157172

Cas号：491-36-1

存储温度：室温

运输条件：常规运输

产品介绍：

Product Application：

4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.

查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/H157172.html