西咪替丁 A

白色或类白色结晶性粉末，几无臭，味苦。易溶于甲醇或稀盐酸，溶于乙醇，略溶于异丙醇，微溶于水。熔点141～143℃。37℃时在水中的溶解度为1.14%。急性毒性LD₅₀小鼠，大鼠(mg/kg)：2600，5000口服；150，106静脉注射；470，650腹腔注射。组胺H2受体拮抗剂。能抑制组胺刺激引起的胃酸分泌，又能抑制由食物、五肽胃泌素、咖啡因和胰岛素等所诱发的胃酸分泌，还能抑制基础胃酸分泌。用于胃及十二指肠溃疡、消化性食道炎、卓-艾综合症。用于治疗消化性溃疡。

White Solid.Competitive histamine H2-receptor antagonist which inhibits gastric acid secretion and reduces pepsin output.antibacterial.White crystals with a slight sulfur-mercaptan odor.Slightly water soluble.Flash point data for Cimetidine are not available. Cimetidine is probably combustible.Widely used H 2 histamine antagonist which has more recently been described as an inverse agonist. Also a potent I 1 imidazoline binding site ligand.