aladdin 阿拉丁 P425290 己酮可可碱 6493-05-6 10mM in DMSO

中文名：己酮可可碱

英文名：Pentoxifylline

中文别名：3,7-二甲基-1-(5-氧代己基)黄嘌呤|3,7-二氢-3,7-二甲基-1-(5-氧代己基)-1H-嘌呤-2,6-二酮|1-(5-氧代己基)可可碱

英文别名：pentoxifylline|Trental|6493-05-6|Oxpentifylline|Pentoxifyllin|Pentoxyphylline|Torental|Pentoxiphyllium|Vazofirin|Dimethyloxohexylxanthine|3,7-Dimethyl-1-(5-oxohexyl)xanthine|Pentoxiphyllin|Pentoxiphylline|Pentoxyfylline|1-(5-Oxohexyl)theobromine|Rentylin|

纯度：10mM in DMSO

货号：P425290

包装：1ml

Cas号：6493-05-6

存储温度：-80℃储存

产品介绍：

Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor. Target: PDE Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity. In addition, pentoxifylline improves red blood cell deformability, reduces blood viscosity and decreases the potential for platelet aggregation and thrombus formation. Pentoxifylline is also an antagonist at adenosine 2 receptors . Pentoxifylline is generally well tolerated. Based on the totality of the available evidence, it is possible that pentoxifylline could have a place in the treatment of IC as a means of improving walking distance and as a complimentary treatment assuming all other essential measures such as lifestyle change, exercise and treatment for secondary prevention have been taken into account . Pentoxifylline reduce AST and ALT levels and may improve liver histological scores in patients with NALFD/NASH, but did not appear to affect cytokines. Large, prospective, and well-designed randomized, controlled studies are needed to address this issue .

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