aladdin 阿拉丁 D413851 杜贝马丁尼（TP-0903） 1341200-45-0 98%

中文名：杜贝马丁尼（TP-0903）

英文名：Dubermatinib(TP-0903)

纯度：Moligand™，≥98%

货号：D413851

Cas号：1341200-45-0

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Dubermatinib(TP-0903) TP-0903 is a potent and selective AXL Inhibitor with IC50 of 27 nM. TP-0903 is highly effective in inducing apoptosis .

Targets

Axl (Cell-free assay) 27 nM

In vitro

In pancreatic cancer cells (PSN-1), TP-0903 shows strong antiproliferative activity with IC50 of 6 M. TP-0903 also induces strong G2/M arrest by potently inhibiting Aurora A and B. [1] In CLL B cells from all the patients with CLL, TP-0903 causes a dose-dependent induction of massive apoptosis by targeting phosphorylated Axl, and overcomes CLL BMSC-mediated protection of CLL B cells from apoptosis.

In vivo

In the adult rat hippocampus, the intracerebroventricular administration of SAG (2.5 nM) significantly increases the number of newly generated cells and extends survival of hippocampal cells. In mice, SAG (20 μg/g, i.p.) effectively prevents GC-induced neonatal cerebellar developmental abnormalities.

Cell Research(from reference)

Cell lines：PSN-1 cells 

Incubation Time：96 hours 

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