aladdin 阿拉丁 C129833 克拉屈滨 4291-63-8 ≥98%

中文名：克拉屈滨

英文名：Cladribine

应用：It is a chlorinated purine nucleoside with activity against lymphoproliferative disorders, such as hairy cell leukemia (HCL) and multiple myeloma (MM). 2-CdA resists ADA degradation and is phosphorylated to CdATP in lymphocytes. CdATP incorporation into DNA induces strand breaks and the activation of apoptosis. 2-CdA may also be used in studies involving the inhibition of DNA polymerase(s). Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK).

纯度：Moligand™，≥98%

货号：C129833

Cas号：4291-63-8

存储温度：2-8°C储存

运输条件：低温运输

产品介绍：

Cladribine是一种腺苷脱氨酶抑制剂，作用于U266， RPMI8226，和MM1.S细胞，IC50分别约为2.43 μM， 0.75 μM，和0.18 μM。

最大吸收波长265(EtOH aq.) nm

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