aladdin 阿拉丁 G413750 GNE-9605 1536200-31-3 98%

中文名：GNE-9605

英文名：GNE-9605

纯度：Moligand™，≥98%

货号：G413750

Cas号：1536200-31-3

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

GNE-9605 GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with K i and IC50 of 2 nM and 19 nM, respectively.

Targets

LRRK2 ; LRRK2 2 nM(Ki); 19 nM

In vitro

GNE-9605 is highly potent against LRRK2 in both biochemical (Ki = 2.0 nM) and cellular (IC50 = 19 nM) assays. In vitro human MDR1 permeability data, GNE-9605 exhibits excellent brain penetration in higher species.

In vivo

In vivo rat PK studies with GNE-9605 (1 mg/kg, p.o.) demonstrates a total plasma clearance of 26 mL/min/kg with excellent oral bioavailability (90%). In BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation, GNE-9605 (10 and 50 mg/kg, i.p.) inhibits in vivo LRRK2 Ser1292 autophosphorylation.

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