aladdin 阿拉丁 N130078 川皮苷 478-01-3 >95.0%(HPLC)

中文名：川皮苷

英文名：Nobiletin

中文别名：蜜橘黄素

英文别名：SPBio_001654|NC00186|Spectrum3_000921|2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one|GTPL12446|HMS2234A09|MFCD03273560|AKOS015965334|FT-0686667|MLS000759462|NSC76751|2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one|D65ILJ7

纯度：>95.0%(HPLC)

货号：N130078

包装：100mg、10mg、50mg

Cas号：478-01-3

存储温度：-20°C储存

产品介绍：

Nobiletin is a flavanoid with antioxidant and anti-inflammatory properties found in the rind of tangerines. The compound has been observed to inhibit the phosphorylation of MEK (mitogen-activated protein kinase). Nobiletin has also been documented to suppress the expression of MMP-1 (matrix metalloproteinases), MMP-3 and MMP-9 that are involved in the breakdown of the extracellular matrix during tumor metastasis. In vitro studies of Nobiletin on varying cancer cell lines and on the chick egg has shown the anti-angiogenic effects of Nobiletin throμgh down regulation of ERK 1, ERK 2 and c-Jun N-terminal kinase, and transcriptional factors c-Jun and Stat3. The compound also suppressed proliferation, migration and tube formation on matrigel of HUVEC cells stimulated with growth supplement. Nobiletin has demonstrated to attenuate NF-κB transcriptional activation, NO and PGE2 production, NOS2 (inducible nitric oxide synthase) and Cox-2 (cyclooxygenase-2) expression.An antioxidant and anti-inflammatory that Inhibits the phosphorylation of MEK.

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