141758-74-9/艾塞那肽/Exenatide

Product Name：Exenatide

CAS No.：141758-74-9

Synonyms：艾塞那肽

Catalog No.：LT-O040

Brand：Go Top peptide（杭州固拓）

Description：Exendin-4 (Exenatide) 是一种长效的glucagon-likepeptide-1 受体激动剂(IC50: 3.22 nM)，是由 39 个氨基酸组成的多肽。艾塞那肽是一种新型diabetes药物属于肠hypoglycemic素类似物，Exendin-4能激活GLP-1受体，使该受体增加胰腺腺泡细胞(pancreatic acinar cells）的细胞内cAMP水平，但对VIP受体无效果。

艾塞那肽是一种新型糖尿病治疗药物,属于肠降血糖素类似物，是肠促胰素类似物家族的个成员，经人工合成的多肽类化合物，可以模拟自然状态下分泌的GLP-1在体内的生理行为，与人胰高血糖素样肽-1(GLP-1)的效果类似，可促进葡萄糖依赖的胰岛素分泌，抑制不适当的葡萄糖依赖的胰高血糖素分泌，减慢胃排空，改善外周组织对胰岛素的敏感性，充分控制血糖。临床上主要用于治疗二甲双胍、磺酰脲类或二甲双胍和磺酰脲类联合应用不能很好地控制血糖的Ⅱ型糖尿病患者。

Exendin-4 (Exenatide) is a long-acting glucagon-like receptor agonist (IC50: 3.22 nM) composed of 39 amino acids. Exennatide is a new type of diabetes drug belonging to the class of intestinal hyperglycemics. Exendin-4 can activate the GLP-1 receptor, causing it to increase intracellular cAMP levels in pancreatic acinar cells, but has no effect on VIP receptors.

Exenatide is a new type of drug for treating diabetes. It belongs to the incretin analog and is the first member of the incretin analog family. The synthetic polypeptide compounds can simulate the physiological behavior of GLP-1 secreted in the natural state in vivo, similar to the effect of human glucagon like peptide-1 (GLP-1), which can promote glucose dependent insulin secretion and inhibit inappropriate glucose dependent glucagon secretion, Slow down gastric emptying, improve peripheral tissue sensitivity to insulin, and fully control blood sugar. Clinically, it is mainly used to treat type II diabetes patients who can not control blood sugar well by metformin, sulfonylureas or the combination of metformin and sulfonylureas.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

申明：产品仅供科研使用

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