多粘菌素B阳离子肽NAB741/1179330-52-9/SPR741

Product Name：SPR741

CAS No.：1179330-52-9

Synonyms：多粘菌素B阳离子肽NAB741

Catalog No.：218P439

Brand：HongTide（上海鸿肽生物）

Description：SPR741是一种衍生自多粘菌素B的阳离子多肽，序列中含有9个氨基酸，并且含有酰胺键的环状结构，是一种增效剂分子。SPR741可提高革兰氏阴性细菌外膜的通透性，用于抑制严重的革兰氏阴性细菌感染。SPR741抑制具有多重耐药性的革兰氏阴性细菌。当与抗生素结合使用时，SPR741具有扩展抗生素活性谱的能力。

SPR741 is a cationic peptide derived from Polymyxin B, with a sequence containing 9 amino acids and a cyclic structure containing amide bonds. It is a synergistic molecule. SPR741 can improve the permeability of the outer membrane of Gram negative bacteria and be used to inhibit severe Gram negative bacterial infections. SPR741 inhibits Gram negative bacteria with multiple drug resistance. When used in combination with antibiotics, SPR741 has the ability to expand the antibiotic activity spectrum.

Purity (HPLC) ≥95.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

Sequence(1-letter code)	Ac-T-{d-S}-Dab-Dab-{d-F}-L-Dab-Dab-T(Lactam: Dab3-Thr9)
Sequence(3-letter code)	Ac-Thr-D-Ser-Dab-Dab-D-Phe-Leu-Dab-Dab-Thr-OH(Lactam: Dab3-Thr9)
Peptide Structure
Molecular Formula	C44H73N13O13
Molecular Weight	992.13

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