CXCR4拮抗剂多肽/Balixafortide/1051366-32-5

Product Name：Balixafortide

CAS No.：1051366-32-5

Synonyms： CXCR4拮抗剂多肽

Catalog No.：218P272

Brand：HongTide（上海鸿肽生物）

Description：Balixafortide (POL6326) 是一种有效的、选择性的，耐受性好的肽类 CXCR4 拮抗剂多肽，序列中含有16个氨基酸，其中包含，其IC50 小于10 nM。Balixafortide 对 CXCR4 的选择性比包括 CXCR7 在内的许多受体高出 1000 倍。Balixafortide 以 IC50 < 10 nM 阻断 β-arrestin 募集和钙通量。Balixafortide 还是一种有效的造血干细胞和祖细胞 (HSPC) 动员剂，并具有抗癌作用。

Balixafortide (POL6326) is an effective, selective, and well tolerated peptide CXCR4 antagonist peptide with 16 amino acids in its sequence, including an IC50 of less than 10 nM. Balixafortide has a selectivity of 1000 times higher for CXCR4 than many receptors, including CXCR7. Balixafortide blocked with IC50<10 nM β- Arrestin recruitment and calcium flux. Balixafortide is also an effective mobilization agent for hematopoietic stem cells and progenitor cells (HSPCs), and has anticancer effects.

Purity (HPLC) ≥95.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

Sequence(1-letter code)	Cyclo(ACSA-{D-Pro}-{Dab}-RYCYQK-{D-Pro}-PYH) (Disulfide bridge: Cys2-Cys9)]
Sequence(3-letter code)	Cyclo(Ala-Cys-Ser-Ala-D-Pro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro-Tyr-His）（Disulfide bridges Cys2-Cys9）
Peptide Structure
Molecular Formula	C84H118N24O21S2
Molecular Weight	1864.14

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