类H2 relaxin多肽/(B7-33)H2/B7-33 relaxin/B7-33

Product Name：B7-33

CAS No.：N/A

Synonyms：(B7-33)H2；B7-33 relaxin；类H2 relaxin多肽

Catalog No.：218P235

Brand：HongTide（上海鸿肽生物）

Description：B7-33是一种人工设计的类似于H2 relaxin的多肽，使一条由27个氨基酸组成的多肽。B7-33通过优先与磷酸化丝裂原活化蛋白激酶胞外信号调节激酶，从而激活松弛素肽受体1的信号传导。在动物模型实验中可以得出B7-33可减轻心肌细胞死亡和内质网应激，保护心脏功能，对小鼠急性心肌损伤具有保护作用。同时B7-33在体外成纤维细胞、大鼠和小鼠体内纤维化模型中被证明能特异性结合松弛素受体RXFP1，并优先激活与抗纤维化作用相关的通路，而无副作用。

B7-33 is an artificially designed peptide similar to H2 relaxin, consisting of 27 amino acids. B7-33 activates the extracellular signal regulated kinase of protein kinase by preferentially phosphorylating mitogen, thereby activating the signal transduction of relaxin peptide receptor 1. In the animal model experiment, it can be concluded that B7-33 can reduce myocardial cell death and endoplasmic reticulum stress, protect the heart function, and have a protective effect on acute myocardial injury in mice. At the same time, B7-33 has been shown to specifically bind to the relaxin receptor RXFP1 in vitro fibroblasts, rat and mouse models of fibrosis, and preferentially activate pathways related to anti fibrosis effects without side effects.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

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