达伐林肽/863919-85-1/Davalintide

Product Name：Davalintide

CAS No.：863919-85-1

Synonyms：达伐林肽

Catalog No.：218P232

Brand：HongTide（上海鸿肽生物）

Description：Davalintide是人类胰淀素的第二代多肽物质，序列中具有37个氨基酸，并且包含一对二硫键，具有抗高血糖活性。半衰期与胰淀素相似的Davalintide通过模仿胰淀素，减缓胃排空，抑制消化分泌物（胃酸、胰酶和胆汁），减少胰高血糖素分泌，增加饱腹感，这些作用会导致血糖水平下降。此外，Davalintide与胰淀素、降钙素和降钙素相关肽受体具有高亲和力结合。与胰淀素相比，Davalintide由于其受体解离缓慢而表现出较长的作用时间。

Davalintide is a second-generation peptide substance of human amylin, with 37 amino acids in its sequence and a pair of disulfide bonds, exhibiting anti hyperglycemic activity. Davalintide, which has a half-life similar to amylin, slows gastric emptying, inhibits digestive secretions (gastric acid, pancreatic enzyme and bile), reduces glucagon secretion, and increases satiety by imitating amylin. These effects will lead to a decrease in blood sugar levels. In addition, Davalintide has high affinity to amylin, Calcitonin and Calcitonin related peptide receptors. Compared with amylin, Davalintide exhibits a longer action time due to its slow receptor dissociation.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

Sequence(1-letter code)	KCNTATCVLGRLSQELHRLQTYPRTNTGSNTY-NH2(Disulfide bridge：Cys2-Cys7)
Sequence(3-letter code)	H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Val-Leu-Gly-Arg-Leu-Ser-Gln-Glu-Leu-His-Arg-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2(Disulfide bridge：Cys2-Cys7)
Peptide Structure
Molecular Formula	C152H248N50O49S2
Molecular Weight	3624.03

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