4-O-甲基和厚朴酚 4-O-Methylhonokiol

Wuhan hengheda Pharm offers high quality 4-O-Methylhonokiol, 4-O-Methylhonokiol  is a naturally occurring lignan derived primarily from the bark and seeds of Magnolia officinalis and related species, which have been utilized in traditional medicine for centuries. Chemically, it is a methylated derivative of honokiol, characterized by the addition of a methoxy group (-OCH₃) at the 4-position of the biphenyl core structure. This modification enhances its lipophilic properties, potentially improving membrane permeability and bioavailability compared to its parent compound. With a molecular formula of C₂₁H₂₄O₂ and a molecular weight of 316.4 g/mol, 4-O-methylhonokiol exhibits structural similarities to other magnolia-derived bioactive compounds, such as honokiol and magnolol, yet demonstrates distinct pharmacological profiles due to its unique substitution pattern.

Extensive preclinical studies have highlighted 4-O-methylhonokiol’s multifaceted biological activities. It exhibits potent anti-inflammatory and antioxidant effects, primarily through the inhibition of NF-κB and MAPK signaling pathways, making it a candidate for treating chronic inflammatory conditions, including neurodegenerative diseases and metabolic disorders. Furthermore, its anxiolytic and neuroprotective properties—mediated via modulation of GABAergic systems and activation of Nrf2-mediated antioxidant responses—suggest therapeutic potential for anxiety, depression, and Alzheimer’s disease. Emerging evidence also points to anti-cancer activity, where it induces apoptosis and suppresses metastasis in various cancer cell lines by targeting PI3K/AKT and Wnt/β-catenin pathways. Additionally, its ability to improve insulin sensitivity and mitigate oxidative stress in metabolic models underscores its relevance in addressing obesity-linked complications. Despite promising preclinical data, further research is required to evaluate its pharmacokinetics, safety profile, and efficacy in clinical settings, paving the way for potential pharmaceutical or nutraceutical applications.