4'-O-Methylhonokiol

Name: 4'-O-Methylhonokiol
CAS#: 68592-15-4
Chemical Formula: C19H20O2
Exact Mass: 280.1463
Molecular Weight: 280.367
Elemental Analysis: C, 81.40; H, 7.19; O, 11.41

Description: 4'-O-Methylhonokiol is a phenol that has been found in M. grandiflora and has diverse biological activities. It is active against the bacteria B. subtilis, S. aureus, and M. smegmatis and the fungus T. mentagrophytes. 4'-O-Methylhonokiol inhibits LPS-induced activation of NF-kB and production of nitric oxide in RAW 264.7 macrophages. In vivo, 4'-O-Methylhonokiol reduces carrageenan-induced paw edema in mice. It reduces neuronal apoptosis and escape latency in the Morris water maze in a mouse model of Alzheimer's disease induced by amyloid-β 1-42 when administered at a dose of 1 mg/kg.3 4-O-methylhonokiol also reduces plasma cholesterol and triglyceride levels, ameliorates hepatic steatosis, and improves insulin resistance in a mouse model of high-fat diet-induced obesity.

IUPAC/Chemical Name: 3',5-diallyl-4'-methoxy-[1,1'-biphenyl]-2-ol

InChi Key: OQFHJKZVOALSPV-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H20O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h4-5,8-13,20H,1-2,6-7H2,3H3

SMILES Code: C=CCC1=CC(C2=CC(CC=C)=C(C=C2)OC)=C(C=C1)O

Appearance: Solid powder