D型穿膜肽GO-203/1222186-26-6/GO-203

Product Name：GO-203

CAS No.：1222186-26-6

Synonyms：D型穿膜肽GO-203

Catalog No.：218P126

Brand：HongTide（上海鸿肽生物）

Description：GO-203是一种D型氨基酸的多肽片段，序列中含有16个氨基酸，具有细胞通透性，能抑制MUC1-C二聚化，因而抑制其致瘤作用。GO-203对过表达MUC1的SKCO-1和Colo-205结肠癌细胞处理以GO-203能下调TIGAR蛋白。GO-203在大肠癌细胞中能调节AKT-S6K1-elF4A信号，抑制p-AKT。GO-203的处理还可导致ROS的增加、线粒体跨膜电位损失。体内研究：在小鼠移植瘤模型中，GO-203可有效地抑制MUC1阳性的大肠癌细胞的生长和生存。它在乳腺移植瘤、前列腺移植瘤以及肺癌和某些恶性血液病中有抗瘤活性。

GO-203 is a peptide fragment of D-type amino acids, containing 16 amino acids in its sequence. It has cellular permeability and can inhibit MUC1-C dimerization, thereby inhibiting its tumorigenic effect. GO-203 can downregulate TIGAR protein in SKCO-1 and Colo-205 colon cancer cells overexpressing MUC1. GO-203 can regulate AKT-S6K1-elF4A signaling and inhibit p-AKT in colorectal cancer cells. The treatment of GO-203 also led to the increase of ROS and the loss of mitochondrial transmembrane potential. In vivo research: In a mouse transplanted tumor model, GO-203 can effectively inhibit the growth and survival of MUC1 positive colorectal cancer cells. It has anti-tumor activity in breast transplant tumors, prostate transplant tumors, lung cancer, and certain malignant hematological diseases.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

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