胰淀素受体Amylin, amide, human/122384-88-7/糖尿病相关肽

Product Name：Amylin, amide, human acetate

CAS No.：122384-88-7

Synonyms：糖尿病相关肽(胰岛淀粉样肽)

Catalog No.：106P01

Brand：HongTide（上海鸿肽生物）

Description：Amylin,amide,human acetate是一种37个氨基酸的多肽，是一种与胰岛素共分泌的胰腺激素，在代谢和葡萄糖稳态中发挥独特的作用。能抑制胰高血糖素分泌，延迟胃排空，并作为饱腹剂。MCF-7 细胞内源性表达人胰淀素受体 CTR1 和 CTR2。 用胰淀素、酰胺、人刺激受体导致产生 cAMP。 Amylin, amide, human (0.001 nM-1000 μM) 导致 EC50 为 35.2±7.5 nM。通过皮下途径注射到不同的瑞士雄性小鼠组中。 观察到游离胰淀素的典型 PK 曲线，半衰期为23分钟。

Amylin, Amide, Human Acetate is a peptide with 37 amino acids, which is a pancreatic hormone secreted together with insulin and plays a unique role in metabolism and glucose homeostasis. It can inhibit the secretion of glucagon, delay gastric emptying, and serve as a satiety agent. MCF-7 cells express endogenous human amylin receptors CTR1 and CTR2. Stimulating receptors with amylin, amides, and humans leads to the production of cAMP. Amylin, amide, human (0.001 nM-1000  μ M) Resulting in an EC50 of 35.2 ± 7.5 nM. Injected subcutaneously into different groups of Swiss male mice. A typical PK curve for free amylin was observed, with a half life of 23 minutes.

Purity (HPLC) ≥90.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

Sequence(1-letter code)	KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH2(Disulfide bridge：Cys2-Cys7)
Sequence(3-letter code)	H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Disulfide bond：Cys2-Cys7)
Peptide Structure
Molecular Formula	C165H261N51O55S2
Molecular Weight	3903.32

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