抑制剂Cenupatide/1006388-38-0/上海鸿肽抑制剂多肽

Product Name：Cenupatide

CAS No.：1006388-38-0

Synonyms：Ac-Arg-Aib-Arg-α(Me)Phe-NH2；抑制剂Cenupatide

Catalog No.：218P027

Brand：HongTide（上海鸿肽）

Description：Cenupatide是一种尿激酶纤溶酶原激活物受体 (uPAR) 抑制剂候选药物，是一条由4个氨基酸组成的直链小分子多肽，序列中含有两个非天然氨基酸。Cenupatide抑制uPAR与甲酰肽受体(FPR)的结合可以改善链脲佐菌素(STZ)诱导的糖尿病大鼠模型中的肾脏损伤。实验发现Cenupatide可恢复STZ诱导的uPA水平和活性上调，而足细胞上的uPAR和(s)uPAR不受影响。同事在肾小球中，Cenupatide能抑制FPR2表达，表明该药物可能作用于下游uPAR，并恢复了αvβ3整合素/Rac-1 途径的活性增加，表明uPAR在调节足细胞功能中的主要作用。

Cenupatide is a candidate drug for urokinase plasminogen activator receptor (uPAR) inhibitor. It is a straight-chain small-molecule peptide composed of four amino acids and contains two unnatural amino acids in its sequence. Cenupatide inhibits the binding of uPAR to formyl peptide receptor (FPR), which can improve the renal damage in the model of streptozotocin (STZ) - induced diabetes rats. It was found that Cenupatide could restore the up-regulation of uPA level and activity induced by STZ, while uPAR and (s) uPAR on podocytes were not affected. In the glomerulus, Cenupatide can inhibit the expression of FPR2, indicating that the drug may act on the downstream uPAR and recover α v β 3 The increased activity of integrin/Rac-1 pathway indicates that uPAR plays a major role in regulating podocyte function.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

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