38899-05-7D-Glucosamine-2-sulfate (sodium salt)

产品属性：

Cas No.38899-05-7

别名 N/A

化学名 N/A

分子式 C6H12NO8S?Na

分子量 281.2

溶解度 Soluble in DMSO

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
D-Glucosamine-2-sulfate (GlcN-2S), a sulfate derivative of glucosamine, is derived from chitin and has anti-inflammatory effects. In vitro, it reduces expression of inflammatory markers, including IL-1β, COX-2, IL-6, and TNF-α in IL-1β-activated human chondrosarcoma SW1353 cells at a minimum effective concentration of 1 μM. At the same concentration, it limits expression of matrix metalloproteinase-3 (MMP-3) and a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), both markers of matrix degradation. Treating human primary chondrocytes with GlcN-2S stimulates proteoglycan production at a dose of 10 μg/mL and adhesion to fibronectin at a concentration of 50 μM.