基本信息 产品详情 公司简介 推荐产品
网站主页 化工产品目录 生物化工 抑制剂 代谢(Metabolism) Factor Xa 抑制剂 依度沙班对甲苯磺酸盐一水化合物 Edoxaban tosylate monohydrate
  • 1229194-11-9Edoxaban tosylate monohydrate

1229194-11-9Edoxaban tosylate monohydrate

Edoxaban tosylate monohydrate
1229194-11-9
询价 1盒 起订
上海 更新日期:2024-12-25

上海一研生物科技有限公司

VIP3年
联系人:吴菲
电话:021-69985186拨打
手机:13611928337 拨打
邮箱:3427709316@qq.com

产品详情:

中文名称:
Edoxaban tosylate monohydrate
英文名称:
Edoxaban tosylate monohydrate
CAS号:
1229194-11-9
品牌:
一研
保存条件:
Store at -20°C
产品类别:
抑制剂
Cas:
1229194-11-9

产品属性:

产品名称

规格

CAS

型号

Edoxaban tosylate monohydrate

10mM (in 1mL DMSO) 5mg 10mg 50mg 200mg

1229194-11-9

EY-Y0164748

Cas No.1229194-11-9

别名

化学名 N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide;4-methylbenzenesulfonic acid;hydrate

分子式 C31H40ClN7O8S2

Edoxaban tosylate monohydrate.png

分子量 738.27

溶解度 36.9 mg/mL in DMSO, 5.78 mg/mL in EtOH with ultrasonic and warming

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述:
Factor Xa (FXa), a key serine protease, is a promising target enzyme for the prophylaxis and treatment of thromboembolic diseases. Edoxaban tosylate monohydrate is a novel antithrombotic agent that directly inhibits FXa activity.

In vitro: Edoxaban tosylate monohydrate (DU-176b) inhibited FXa with Ki values of 0.561 nM for free FXa, 2.98 nM for prothrombinase, and exhibited >10 000-fold selectivity for FXa. DU-176b doubled prothrombin time and activated partial thromboplastin time in human plasma. DU-176b did not impair platelet aggregation by ADP, collagen or U46619 [1].

In vivo: DU-176b dose-dependently inhibited thrombus formation in rat and rabbit thrombosis models, although bleeding time in rats was not significantly prolonged at an antithrombotic dose [1].

Clinical trial: A previous study determined the mass balance and pharmacokinetics of edoxaban in humans after oral administration of [14C]edoxaban. The mass balance of edoxaban study showed unchanged edoxaban as the most abundant component. Edoxaban was eliminated through multiple pathways, but each accounts for only a small amount of overall elimination [2].

References:

[1] Furugohri T, Isobe K, Honda Y, Kamisato-Matsumoto C, Sugiyama N, Nagahara T, Morishima Y, Shibano T.  DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost. 2008;6(9):1542-9.

[2] Bathala MS, Masumoto H, Oguma T, He L, Lowrie C, Mendell J.  Pharmacokinetics, biotransformation, and mass balance of edoxaban, a selective, direct factor Xa inhibitor, in humans. Drug Metab Dispos. 2012;40(12):2250-5.


1229194-11-9;C31H40ClN7O8S2;Edoxaban tosylate mo;

公司简介

上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要从事免疫学、分子生物学和常规生化试剂等为一体的科研产品销售企业,公司自成立以来,秉承""全心全意服务于科研工作者""的企业理念,立足生物科技领域,运用生物技术和科研试剂,发展现代生物科技,为各类大中小医院及其它医疗机构、高等院校、科研院所、企事业单位提供优质的产品,服务生物科技领域的科学研究人员。 公司具有对普通货物、冷藏及冷冻仓库的存储、包装及运输能力。 公司将始终坚持信誉立业、以人为本、质量保证、诚信服务的宗旨,不断拼搏,开拓进取,与各界朋友携手共创美好未来。

成立日期 (11年)
注册资本 100
员工人数 50-100人
年营业额 ¥ 100万以内
经营模式 工厂,试剂
主营行业 生化试剂,抗体,细胞培养,分子生物学,免疫安全

Edoxaban tosylate monohydrate相关厂家报价 更多

内容声明
拨打电话 立即询价