56121-42-7Asperglaucide

产品属性：

Cas No.56121-42-7

别名 N/A

化学名 N/A

分子式 C27H28N2O4

分子量 444.5

溶解度 DMSO: soluble,Ethanol: soluble

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Asperglaucide is an amide originally isolated from P. aurantiacum that has diverse biological activities, including anti-inflammatory, antibacterial, antioxidant, and anticancer properties.1,2,3,4 Asperglaucide inhibits production of nitric oxide (NO), prostaglandin E2 , and IL-1β in LPS-stimulated BV-2 microglial cells (IC50s = 49.7, 51.5, and 40.4 μM, respectively).2 It is active against Gram-negative bacteria (MICs = 0.05-0.10 mg/ml) and has antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl and Trolox equivalent antioxidant capacity (TEAC) assays (EC50s = 9.51-78.81 μg/ml).3 Asperglaucide decreases viability of U87 and U251 cancer cells in vitro when used at concentrations ranging from 10 to 100 μM and reduces tumor growth when administered at a dose of 1 mg via intratumoral injection in a U87 mouse xenograft model.4

1.Banerji, A., and Ray, R.Aurantiamides: A new class of modified dipeptides from Piper aurantiacumPhytochemistry20(9)2217-2220(1981) 2.Yoon, C.S., Kim, D.C., Lee, D.S., et al.Anti-neuroinflammatory effect of aurantiamide acetate from the marine fungus Aspergillus sp. SF-5921: Inhibition of NF-κB and MAPK pathways in lipopolysaccharide-induced mouse BV2 microglial cellsInt. Immunopharmacol.23(2)568-574(2014) 3.Tamokou, J.D., Simo Mpetga, D.J., Keilah Lunga, P., et al.Antioxidant and antimicrobial activities of ethyl acetate extract, fractions and compounds from stem bark of Albizia adianthifolia (Mimosoideae)BMC Complement. Altern. Med.1299(2012) 4.Yang, Y., Zhang, L.H., Yang, B.X., et al.Aurantiamide acetate suppresses the growth of malignant gliomas in vitro and in vivo by inhibiting autophagic fluxJ. Cell. Mol. Med.19(5)1055-1064(2015)