西仑吉肽

Product Name：Cilengitide

CAS No.：188968-51-6

Synonyms：西仑吉肽

Catalog No.：GT-A044

Brand：Go Top peptide（杭州固拓）

Description：Cilengitide (EMD 121974) 是一种强效的整合素拮抗剂，IC₅₀ 分别为 0.61 nM (α_νβ₃)，8.4 nM (α_νβ₅) 和 14.9 nM (α₅β₁)。Cilengitide 抑制 α_νβ₃ 和 α_νβ₅ 与玻连蛋白结合，IC₅₀ 值分别为 4 和 79 nM。Cilengitide 能够抑制 TGF-β/Smad 信号通路，调节 PD-L1 表达。Cilengitide 诱导凋亡 (apoptosis)，在对胶质母细胞瘤和其他癌症的研究中也显示出抗血管生成的作用，Cilengitide是一种由5个氨基酸组成的多肽。

Cilengitide (EMD 121974) is a potent integrin antagonist with IC50 of 0.61 nM, respectively（ ανβ 3) 8.4 nM（ ανβ 5) And 14.9 nM（ α five β 1) . Cilengitide inhibition ανβ 3 and ανβ 5 binds to fibronectin, with IC50 values of 4 and 79 nM, respectively. Cilengitide can inhibit TGF- β/ The Smad signaling pathway regulates PD-L1 expression. Cilengitide induces apoptosis, which has also shown anti angiogenic effects in research on glioblastoma and other cancers. Cilengitide is a peptide composed of five amino acids

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

申明：产品仅供科研使用

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