非罗考昔|Firocoxib|189954-96-9

产品描述

等级：活性药物成分（API）

化学名称:3 - (Cyclopropylmethoxy) 5、5-dimethyl-4 - (4 - (methylsulfonyl)苯基)furan-2——(5小时)

分子式：C17H20O5S

分子量：336.403

规范：按照ChP/USP/EP建立企业标准

外观:粉

总杂质：不大于2.0%

纯度：不低于98%

残留溶剂：完全符合ICH Q3C要求

致突变杂质：完全符合ICH M8

亚硝胺评估：可用

粒度：可根据客户要求进行普通级或研磨/筛分。

储存方法：室温

生产能力：商用

标准包装：1kg/袋，5kg/袋，或根据客户要求。

产品用途

Firocoxib是一种选择性COX-2抑制剂（在离体猫血中，COX-2和COX-1的ic50分别为0.13和7.5 μM）。抑制lps诱导的前列腺素E2 （PGE2）的产生。在离体的狗、马和猫全血中。Firocoxib分别以每天5 mg/kg和0.1 mg/kg的剂量给药，可减少患有骨关节炎的狗和马的跛行，诱导镇痛，并改善活动范围。含有firocoxib的制剂已用于患有骨关节炎的狗和马。

Firocoxib以Equioxx和Previcox等品牌销售，是一种COX-2抑制剂（coxib）类非甾体抗炎药，批准用于马（Equioxx）和犬（Previcox）。Firocoxib是美国食品和药物管理局批准的第一个用于马的COX-2抑制剂。Firocoxib不打算或批准用于人类医学。

2004年7月，Firocoxib API在美国被批准用于犬类兽医，2016年7月被批准用于马类。Firocoxib是一种用于马和狗的通用药物。

联系方式

四川青木制药有限公司

四川省眉山市东坡区经济开发区东区顺江大道南段55号

国际营销部(International):

Email: sales@eastonpharma.cn 

Tel: 028-87827187

国内营销部(Mainland)：

李经理 13880480517   

杨经理 15982276454

Product Description

Grade: Active Pharmaceutical Ingredient(API)

Chemical Name:3-(Cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one

Molecular Formula: C17H20O5S

Molecular Weight: 336.403

Specification: Enterprise Standard established according to ChP/USP/EP

Appearance: Powder

Total impurities: not more than 2.0%

Purity: not less than 98%

Residual Solvents: fully comply with ICH Q3C

Mutagenic impurities: fully comply with ICH M8

Nitrosamine assessment: available

Particle size: regular grade or milling/sieving according to customer’s requirement.

Storage: Room temperature

Production capacity: Commercial

Standard Package: 1kg/bag, 5kg/bag, or according to the customer’s requirement.

Applications 

Firocoxib is a selective inhibitor of COX-2 (IC50s = 0.13 and 7.5 μM for COX-2 and COX-1, respectively, in isolated cat blood). It inhibits LPS-induced production of prostaglandin E2 (PGE2; ) in isolated dog, horse, and cat whole blood ex vivo. Firocoxib decreases lameness, induces analgesia, and improves range of motion in dogs and horses with osteoarthritis when administered at doses of 5 and 0.1 mg/kg per day, respectively. Formulations containing firocoxib have been used in dogs and horses with osteoarthritis.

Firocoxib sold under the brand names Equioxx and Previcox among others, is a nonsteroidal anti-inflammatory drug of the COX-2 inhibitor (coxib) class, approved for use in horses (Equioxx) and for use in dogs (Previcox). Firocoxib is the first COX-2 inhibitor approved by the U.S. Food and Drug Administration for horses. Firocoxib is not intended or approved for use in human medicine.

Firocoxib API was approved for veterinary use in the United States for dogs in July 2004 and for horses in July 2016. Firocoxib is available as a generic medication for horses and for dogs.

Contact Information

Sichuan Qingmu Pharmaceutical Co., Ltd.

Add: No. 55, South Shunjiang Avenue, East Economic Development Zone, Dongpo District, Meishan City, Sichuan, 620036, China

International Marketing Department: 

Email: sales@eastonpharma.cn 

Tel: 0086-28-87827187