大鼠肝星状细胞

肝星状细胞（Hepatic Stellate Cells)  

肝星状细胞（Hepatic Stellate Cells)  是各种致纤维化因素的最终靶细胞，正常情况下肝星状细胞处于静止状态，当肝脏受到炎症或机械刺激等损伤时，肝星状细胞被激活，其表型由静止型转变为激活型。
      
      
       应用方向：

      1）HSC与肝纤维化  
      2）HSC与肝脏发育和再生
      3）HSC与肝肿瘤
      4）HSC与免疫系统
      
         用户反馈：

                                                             （上图为知名药企研发部门提供）
 

       2016-2019 论文引用（部分）：

1. Deng M, Xu L, Xie X et al., .Downregulation of syndecan‑1 expression induces activation of hepatic stellate cells via the TGF‑β1/Smad3 signaling pathway. Mol Med Rep. 2019; 20(1):368-74.

2. 小 Zhang F, Lu S, He J et al., Ligand activation of PPARγ by ligustrazine suppresses pericyte functions of hepatic stellate cells via SMRT-mediated transrepression of HIF-1α. Theranostics 2018; 8(3): 610-26.

3. Zhang F, Jin H, Wu L et al., Diallyl trisulfide suppresses oxidative stress-induced activation of hepatic stellate cells through production of hydrogen sulfide. Oxid Med Cell Longev. 2017; 2017:1406726.

4. Lian N, Jin H, Zhang F et al., Curcumin inhibits aerobic glycolysis in hepatic stellate cells associated with activation of adenosine monophosphate‐activated protein kinase. IUBMB Life. 2016; 68(7):589-96.

5. He L, Hou X, Fan F et al., Quercetin stimulates mitochondrial apoptosis dependent on activation of endoplasmic reticulum stress in hepatic stellate cells. Pharm Biol. 2016,; 54(12):3237-43.

6. Zhang F,  Lu C,  Xu W et al., Curcumin raises lipid content by Wnt pathway in hepatic stellate cell. J Surg Res. 2016; 200(2): 460-6.

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