5-[[4-[（3，4-二氢-6-羟基-2，5，7，8-四甲基-2H-1-苯并吡喃-2-基）甲氧基]苯基]甲基] -2，4-噻唑烷二酮

中文名称

5-[[4-[（3，4-二氢-6-羟基-2，5，7，8-四甲基-2H-1-苯并吡喃-2-基）甲氧基]苯基]甲基] -2，4-噻唑烷二酮； ResulinTM；曲格列酮

英文名字

5-[[4-[（3，4-dihydro-6-hydroxy-2，5，7，8-tetramethyl-2H-1-benzopyran-2-yl）methoxy]phenyl]methyl]-2，4-thiazlidinedione； ResulinTM； Troglitazone

供应商

开曼生物

产品货号

71750-10

产品报价

￥1447.6/10mg

产品说明书

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购买方式

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产品新闻

背景资料

Troglitazone is a TZD which was approved for the treatment of insulin resistance and hyperglycemia in Type II diabetes， under the trade name ResulinTM， but was withdrawn from the market due to hepatotoxicity. Troglitazone is a potent and selective PPAR.gamma. agonist. The EC50 values for transactivation of human and mouse PPAR.gamma. in a cell-based assay are 0.55 and 0.78 uM， respectively. In the same assay system， no activation of PPAR.alpha. and PPAR.delta. was observed at concentrations up to 10 uM. Troglitazone binds to the PPAR.gamma. ligand-binding domain （LBD） but fails to induce interaction of the PPAR.gamma. LBD with the transcriptional coactivators SRC-1， TIF2， AIB1， p300， or TRAP220. Troglitazone also induces cell cycle arrest and apoptosis in several cancer cell lines with an EC50 of 10 uM.

产品描述

Troglitazone is a TZD which was approved for the treatment of insulin resistance and hyperglycemia in Type II diabetes， under the trade name ResulinTM， but was withdrawn from the market due to hepatotoxicity. Troglitazone is a potent and selective PPAR.gamma. agonist. The EC50 values for transactivation of human and mouse PPAR.gamma. in a cell-based assay are 0.55 and 0.78 uM， respectively.{10670} In the same assay system， no activation of PPAR.alpha. and PPAR.delta. was observed at concentrations up to 10 uM. Troglitazone binds to the PPAR.gamma. ligand-binding domain （LBD） but fails to induce interaction of the PPAR.gamma. LBD with the transcriptional coactivators SRC-1， TIF2， AIB1， p300， or TRAP220.{8555} Troglitazone also induces cell cycle arrest and apoptosis in several cancer cell lines with an EC50 of 10 uM.{10669}

保存建议

建议您在收到开曼生物品牌的Troglitazone （10 mg）产品后置于-20度保存，产品有效期为365天.

其他

开曼生物向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.开曼生物可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为开曼生物在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的开曼生物产品以及客户订制化服务.