（2R）-辛基-α-羟基戊二酸酯

中文名称

（2R）-辛基-α-羟基戊二酸酯

英文名字

(2R)-Octyl-α-hydroxyglutarate

供应商

开曼生物

产品货号

16366-5

产品报价

￥3064.6/5mg

产品说明书

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购买方式

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产品新闻

背景资料

α-Hydroxyglutaric acid (2-HG; Item No. 16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder.{26770,26771,26772} Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than α-ketoglutarate.{26773,26775} 2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.{26775,26774,26769} (2R)-Octyl-α-hydroxyglutarate is a cell-permeable derivative of the D-isomer of 2-HG. It has been used to examine the contribution of D-2HG to the oxidative mitochondrial processes of IDH1-mutated cancer cells.{28419}

产品描述

A cell-permeable derivative of the D-isomer of 2-HG; used to examine the contribution of D-2HG to the oxidative mitochondrial processes of IDH1-mutated cancer cells

保存建议

建议您在收到开曼生物品牌的(2R)-辛基-α-羟戊二酸 (5 mg)产品后置于-20℃保存.

其他

开曼生物向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.开曼生物可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为开曼生物在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的开曼生物产品以及客户订制化服务.