人肝铁蛋白

中文名称

【铁蛋白】人肝铁蛋白

英文名字

Human Liver Ferritin

供应商

ProSpec

产品货号

PRO-564

产品报价

￥1610/200ug   ￥6440/1mg   ￥39100/10mg

产品说明书

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购买方式

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产品新闻

背景资料

Ferritin is the main intracellular iron storage protein in prokaryotes and eukaryotes. Ferritin’s major functions are the storage of iron in a soluble and nontoxic state and its release in a controlled fashion. An iron-containing protein complex is found mostly in the intestinal mucosa， spleen， and liver. Ferritin is composed of 24 subunits of the heavy and light chains. Variation in ferritin subunit composition may influence the rates of iron uptake and release in different tissues. Defects in the light chain ferritin gene are linked to a number of neurodegenerative diseases and hyperferritinemia-cataract syndrome. The genes that encode the light and heavy chains are on located different chromosomes. The light chain genes are in chromosome region 19q13.3-q13.4 whilst those for the heavy chain are in chromosome region 11q12-q13. Ferritin is shaped like a hollow sphere， inside which the iron is stored in the Fe（III） oxidation state. The iron is integrated in the mineral ferrihydrite， [FeO（OH）]8[FeO（H2PO4）]， which is attached to the inner wall of the sphere. To release iron once the body needs it， the iron must be altered from the Fe（III） to the Fe（II） oxidation state. Subsequently， the iron leaves through channels in the spherical structure. Therefore， the structure of ferritin is tremendously important for the protein’s ability to store and release iron in a controlled mode.
The amount of ferritin in the blood （serum ferritin level） is directly related to the amount of iron stored in the body. The body has a "buffer" against iron deficiency （if the blood has too little iron， ferritin can release more） and， to a lesser extent， iron overload （if the blood and tissues of the body have too much iron， ferritin can help store the excess iron）.

序列

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来源宿主

人肝脏组织中提取纯化

溶解建议

Sterile Filtered brownish solution. The protein solution is in 0.05M TRIS buffer pH 7.5 containing 1.0M NaCl and 0.09% NaN3.

保存建议

Human Ferritin should be stored at 2-8℃.

其他

ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。 领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。