武汉艾必赛生物有限公司推荐Anti-HMPV Matrix protein/M Polyclonal Antibody,精品抗体

链接：https://www.abinscience.cn/product/34/12962.html

名称：Anti-HMPV Matrix protein/M Polyclonal Antibody

货号：VK777014

种属反应性：Human metapneumovirus (HMPV)

应用：ELISA, IHC, WB

宿主：Rabbit

克隆类型：Polyclonal

同种型：IgG

免疫原：E. coli - derived recombinant HMPV Matrix protein/M (Glu2-Arg254).

靶标：Matrix protein, M protein, M

纯化方式：Purified by antigen affinity column.

Accession号：Q6WB99

状态：Liquid

用途范围：仅用于科研

储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

产品介绍：Anti-HMPV Matrix protein/M Polyclonal Antibody (VK777014, RUO)是艾必赛生物（abinScience）推出的兔源多克隆抗体（IgG），靶向人偏肺病毒（Human metapneumovirus, HMPV）的基质蛋白 M，可作为 HMPV 检测、病毒组装与出芽机制研究及 WB/IHC/ELISA 实验的阳性参照工具。该抗体以 E. coli 表达的重组 HMPV Matrix protein/M（Glu2–Arg254） 为免疫原，经抗原亲和柱纯化，以液体形式保存在 0.01M PBS, pH 7.4（含 50% Glycerol, 0.05% Proclin 300）中；

人偏肺病毒（HMPV）属副黏病毒科肺病毒属，为单股负链 RNA 病毒，是婴幼儿、老年人及免疫低下人群急性呼吸道感染的重要病原，可引起细支气管炎、肺炎等下呼吸道疾病。病毒基质蛋白 M 约 27 kDa，在病毒生命周期中起核心结构调度作用：感染早期可进入细胞核，可能抑制宿主转录；随后经宿主 CRM1 途径转运至细胞质，富集于病毒转录复制包涵体区域；在病毒组装与释放阶段，M 蛋白作为“桥梁”连接核衣壳与脂质双层，驱动病毒以丝状形态完成装配与出芽。

因此，M 蛋白既是 HMPV 病毒形态发生与复制调控的关键效应分子，也是病毒学机制研究、抗病毒靶点筛选及重组抗体/检测试剂开发的重要参照靶标。

产品购买联系方式：027-87433958/17302791434

邮箱：info@abinscience.com

参考文献：

Adjuvant effect of the human metapneumovirus (HMPV) matrix protein in HMPV subunit vaccines. PMID: 25519171

A calcium-fortified viral matrix protein. PMID: 24411575

Multi-epitope vaccine design against human metapneumovirus via reverse vaccinology and molecular modelling. PMID: 41274916

Exploring quercetin based nano formulation in combating human Metapneumovirus infections. PMID: 40132458

Reduced expression of human metapneumovirus matrix protein impacts virus assembly and ribonucleoprotein localization. PMID: 42671868

The human metapneumovirus matrix protein stimulates the inflammatory immune response in vitro. PMID: 21412439

Immunogenicity and protective efficacy of human metapneumovirus virus-like particles produced by a recombinant baculovirus in mice. PMID: 37657510

Evaluation of a Novel Immunochromatographic Assay Using Monoclonal Antibodies against the Matrix Protein of Human Metapneumovirus. PMID: 34655208

Next-generation multi-epitope subunit vaccine design: A computational approach utilizing two stable proteins to combat Human Metapneumovirus (HMPV). PMID: 40829349

Recombinant expression and immunological characterisation of proteins derived from human metapneumovirus. PMID: 21920812

Exploring traditional Chinese medicine for antiviral drug discovery: A computational approach to combat human metapneumovirus (HMPV). PMID: 41546933

Rational design and in silico characterization of a multiepitope mRNA vaccine candidate against human metapneumovirus (hMPV) using reverse vaccinology and immunoinformatics approaches. PMID: 41444309

An in-silico design of a multi-epitope vaccine candidate against human metapneumovirus (HMPV) through prediction of B- and T-cell epitopes and molecular dynamics simlation. PMID: 40730055

Phosphorylation of Human Metapneumovirus M2-1 Protein Upregulates Viral Replication and Pathogenesis. PMID: 27252537

Targeted Proteomics of Human Metapneumovirus in Clinical Samples and Viral Cultures. PMID: 26376123

Human metapneumovirus virus-like particles induce protective B and T cell responses in a mouse model. PMID: 24672031

Acute encephalopathy associated with human metapneumovirus infection. PMID: 24858612

The conserved YAGL motif in human metapneumovirus is required for higher-order cellular assemblies of the matrix protein and for virion production. PMID: 21525358

Lung CD8+ T Cell Impairment Occurs during Human Metapneumovirus Infection despite Virus-Like Particle Induction of Functional CD8+ T Cells. PMID: 26063431

Role of metapneumovirus in viral respiratory infections in young children. PMID: 16891486

Genetic Variability and Sequence Relatedness of Matrix Protein in Viruses of the Families Paramyxoviridae and Pneumoviridae. PMID: 29510403

Imaging analysis of human metapneumovirus-infected cells provides evidence for the involvement of F-actin and the raft-lipid microdomains in virus morphogenesis. PMID: 25408253

Human metapneumovirus nucleoprotein and phosphoprotein interact and provide the minimal requirements for inclusion body formation. PMID: 18931065

Detection of antibodies against human metapneumovirus by Western blot using recombinant nucleocapsid and matrix proteins. PMID: 16789025

Immunogenicity and efficacy of two candidate human metapneumovirus vaccines in cynomolgus macaques. PMID: 18585830

Discovery of Phytochemicals as Inhibitors of Human Metapneumovirus: In-Silico Docking Studies. PMID: 42393873

Diagnosis of human metapneumovirus infection in immunosuppressed lung transplant recipients and children evaluated for pertussis. PMID: 17065270

Comparative evaluation of real-time PCR assays for detection of the human metapneumovirus. PMID: 12904367

Novel Respiratory Syncytial Virus-Like Particle Vaccine Composed of the Postfusion and Prefusion Conformations of the F Glycoprotein. PMID: 27030590

Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread. PMID: 27683250

Characterization of human metapneumovirus from pediatric patients with acute respiratory infections in a 4-year period in Beijing, China. PMID: 21740766

High genetic diversity of the attachment (G) protein of human metapneumovirus. PMID: 15297475

Subtype B avian metapneumovirus resembles subtype A more closely than subtype C or human metapneumovirus with respect to the phosphoprotein, and second matrix and small hydrophobic proteins. PMID: 12686426

Human metapneumovirus-associated respiratory tract infections in the Republic of Ireland during the influenza season of 2003-2004. PMID: 15819862

Immunization of Syrian golden hamsters with F subunit vaccine of human metapneumovirus induces protection against challenge with homologous or heterologous strains. PMID: 17872522

详情请咨询 abinScience 亚洲区官方子公司 —— 武汉艾必赛生物技术有限公司

官方网址：【中文】https://www.abinscience.cn

【英文】https://www.abinscience.com

武汉艾必赛生物技术有限公司成立于 2023 年，是 abinScience 在亚洲地区设立的官方全资子公司，全面负责 abinScience 品牌在亚太市场的科研试剂推广、销售及技术支持工作。

依托严格的产品研发体系和国际化的质量管理标准，武汉艾必赛与 AtaGenix、ProteoGenix 等知名品牌保持长期战略合作，现已构建起涵盖抗体、重组蛋白、工具酶、试剂盒、实验耗材在内的多品类供应体系，面向区域内科研机构、高校实验室与生物医药企业，提供稳定、高效、可信赖的产品与服务。

核心业务覆盖：
✅ 抗体产品（单抗、多抗、重组抗体等）
✅ 蛋白与多肽试剂（标签蛋白、功能蛋白等）
✅ 分子与细胞实验相关耗材
✅ 定制化研发服务（蛋白表达、抗体定制、亲和力成熟等）
✅ 科研供应链整合与项目配套支持

武汉艾必赛始终秉持“Empowering Bioscience Discovery”的理念，为亚太地区的生命科学研究持续注入高质量动能。