文章标题：Immunomodulatory effects of atorvastatin on MRL/lpr mice
作者列表：Sun Jing, Xu Weidong, Wu Zhiying, Cao Caijin, Tan Yane, Zhu Meifang, Wu Hongze, Yu Jianping
影响因子：3.01
期刊：Advances in Rheumatology
发表时间：2022-12-5
DOI:10.1186/s42358-022-00282-z
文献主题：Abstract
Background
Statins have long been extensively prescribed as effective lipid-lowering agents, but statins have also been recognized as novel immunomodulators in recent years. This study was designed to investigate the immunomodulatory effects of atorvastatin on lupus-prone MRL/lpr mice.
Methods
A total of 30 8-week-old female MRL/lpr mice were randomly divided into three groups and orally administered vehicle, atorvastatin orhydroxychloroquine sulfate for 11 weeks. In vivo, the effects of atorvastatin on the survival rate, renal function and spleen index in MRL/lpr mice were examined. Ex vivo, splenic B-cell proliferation was assessed by a Cell Counting Kit-8.
