文章标题：Progesterone attenuates hypertension and autoantibody levels to the angiotensin II type 1 receptor in response to elevated cadmium during pregnancy
期刊：PLACENTA
作者列表：Qiong Zhang, Yinping Huang, Keke Zhang, Yan Yan, Jie Wu, Fan Wang, Yuan Zhao, Huifang Xu, Wei Jiang, Danyang Yu, Yongtao Chen, Duyun Ye
发表时间：2017-12-7
影响因子：2.759
DOI:10.1016/j.placenta.2017.12.004
主要研究成果：Abstract
Introduction
Preeclampsia is associated with the presence of pathogenic angiotensin-receptor-activating autoantibodies. Cadmium is an increasingly prevalent environmental pollutant that can mimic oestrogens, which may enhance immunoglobulin production. Progesterone exerts opposite effects to oestrogen.
Methods
We measured the levels of cadmium and progesterone in preeclamptic patients and controls. Pregnant rats exposed to cadmium (0.125 mg/kg body weight) from gestational day 9–12 were treated with/without progesterone (3 mg/kg) beginning from gestational day 9 to delivery. We analysed the main features of preeclampsia and circulating level of the angiotensin II type 1 receptor agonistic autoantibody. We also measured the expression of activation-induced cytosine deaminase in B cells.
