武汉艾必赛生物有限公司推荐Anti-Human CD3 Antibody (SP34),精品抗体

链接：https://www.abinscience.cn/product/40/4316.htm
名称：Anti-Human CD3 Antibody (SP34)

Accession号：P07766

货号：HY057507

种属反应性：Human

宿主：Mouse

形式：Liquid

纯度：>95% as determined by SDS-PAGE.

克隆性：Monoclonal

同种型：IgG2a, kappa

应用：FCM

靶点：T3E, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T-cell surface glycoprotein CD3 epsilon chain

用途范围：仅用于科研

储存：Use  a manual defrost freezer and avoid repeated freeze-thaw cycles. Store  at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C  long term.

产品介绍：Anti-Human  CD3 Antibody (SP34) (HY057507) 是武汉艾必赛生物技术有限公司 (abinScience)  推出的一款高特异性小鼠源单克隆抗体。该抗体靶向人T细胞表面抗原T3/Leu-4的ε链 (T3E/CD3e)，此靶点是T细胞受体 (TCR)  复合物的关键组分，在T细胞的抗原识别与活化信号转导中发挥核心作用。本品克隆号为SP34，同种型为IgG2a, kappa，通过Protein  A/G方法纯化，纯度经SDS-PAGE检测高于95%。该抗体经严格验证适用于流式细胞术  (FCM)，可特异性检测人源样本中CD3ε蛋白的表达。其经典的单克隆抗体结构确保了高度的特异性和批次间的一致性，是进行T细胞免疫分型、免疫功能研究及相关疾病机制探索的可靠工具试剂。

产品购买联系方式：027-87433958/17302791434

邮箱：info@abinscience.com

参考文献：

Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility. PMID: 35271814

Structural basis of assembly of the human T cell receptor-CD3 complex. PMID: 31461748

CD3(+)CD20(+) T cells and their roles in human diseases. PMID: 30639700

CD3 delta immunodeficiency. PMID: 15640687

Optimizing  efficacy and safety of T cell bispecific antibodies: the  interdependence of CD3 and tumor antigen binder affinities in FOLR1 and  CEACAM5 2 + 1 TCBs. PMID: 41196029

Current Knowledge about CD3(+)CD20(+) T Cells in Patients with Multiple Sclerosis. PMID: 39201672

Engineered CD3 antibodies for immunosuppression. PMID: 12930354

CD3-specific antibody-induced active tolerance: from bench to bedside. PMID: 12563296

Characterization of CD3+/CD20+ canine large-cell lymphoma. PMID: 37837199

Back on the scene: Advances and challenges in CD3-related drugs in tumor therapy. PMID: 35489674

Discordant CD3 expression in lymphomas when studied on frozen and paraffin sections. PMID: 7557948

Structure-based engineering of a novel CD3ε-targeting antibody for reduced polyreactivity. PMID: 36991534

Muromonab CD3: a reappraisal of its pharmacology and use as prophylaxis of solid organ transplant rejection. PMID: 8861551

CD3 zeta defects in systemic lupus erythematosus. PMID: 22460144

Combining  CD3/GD2 bispecific T cell engager with human Vgamma9Vdelta2 T cells  facilitates neuroblastoma cell targeting and killing in vitro. PMID:  40489497

Internalization and intracellular fate of TCR-CD3 complexes. PMID: 11100805

[CD3 subunit deficiencies]. PMID: 11212834

Key  links in the physiological regulation of the immune system and disease  induction: T cell receptor -CD3 complex. PMID: 39029632

Rigid crosslinking of the CD3 complex leads to superior T cell stimulation. PMID: 39281668

Atomic-resolution view of complete TCR-CD3 revealed. PMID: 31907795

CD3+  Tumor-Infiltrating Lymphocytes in Breast Carcinoma: Their Prognostic  Role and Association With Clinical Parameters. PMID: 39791074

The TCR/CD3 complex: molecular interactions in a changing structure. PMID: 12371622

The  novel CD16A/anti-CD3 bifunctional protein, eCD16A/anti-CD3-BFP,  redirects T cell cytotoxicity toward antibody-bound target cells. PMID:  39763374

CD3(+)CD8(+)CD28(-) T Lymphocytes in Patients with Lupus Nephritis. PMID: 27446964

Changing roles of CD3 + CD8 low T cells in combating HIV-1 infection. PMID: 36580634

T-cell-receptor isoforms. PMID: 1428396

Expansion of mixed immune cells using CD3/CD161 co-stimulation for the treatment of cancer. PMID: 37100864

CD3+ T cell depletion paradoxically worsens intracerebral hemorrhage through blood-brain barrier disruption. PMID: 40985817

Can we define CD3(+)CD56(+) cells as NKT cells with impunity? PMID: 33662591

Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain. PMID: 7495730

T cell inactivation and cytokine deviation promoted by anti-CD3 mAbs. PMID: 9368773

Moniezia benedeni drives CD3(+) T cells residence in the sheep intestinal mucosal effector sites. PMID: 38371601

Use of CD3 antibodies in transplantation and autoimmune diseases. PMID: 7998111

Proinflammatory CD20(+)CD3(+) T cells as a potential driver of macrophage reprogramming in rheumatoid arthritis. PMID: 41411762

The CD3 epsilon subunit of the TCR contains endocytosis signals. PMID: 10384095

Human  CD3(+)CD56(+)NKT-like cells express a range of complement receptors and  C3 activation has negative effects on these cell activity and effector  function. PMID: 34134908

Implicit Flow Cytometric Diagnosis of Classic Hodgkin Lymphoma Using CD3(+)CD4(+)CD26(-) T-Cells. PMID: 39235202

CD3 zeta and eta chains are produced by alternative splicing from a common gene. PMID: 2150596

The  phenotype of CD3-CD56(bright) and CD3-CD56(dim) natural killer cells in  systemic lupus erythematosus patients and its relation to disease  activity. PMID: 36186836

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武汉艾必赛生物技术有限公司成立于 2023 年，是 abinScience 在亚洲地区设立的官方全资子公司，全面负责 abinScience 品牌在亚太市场的科研试剂推广、销售及技术支持工作。

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核心业务覆盖：
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