长沙上禾生物 黄腐酚 Xanthohumol 中英文简介

产品名称

黄腐酚 (别名：黄腐醇)

Xanthohumol (Xn)

植物来源

桑科植物啤酒花 (Humulus lupulusL.) 的雌花序（蛇麻花）

Female inflorescences (hops) of Humulus lupulusL. (Cannabaceae family)

化学分类

异戊烯化查尔酮 (Prenylated Chalcone)

Prenylated Chalcone

核心成分

黄腐酚 (Xanthohumol)

Xanthohumol

外观性状

黄色至橙黄色结晶性粉末，对光敏感，易氧化变色。

Yellow to orange-yellow crystalline powder. Photosensitive, easily oxidized and discolored.

主要规格

HPLC ≥10% (啤酒花提取物)
HPLC ≥20% (标准提取物)
HPLC ≥98% (高纯单体，科研/医药级)

HPLC ≥10% (Hops Extract)
HPLC ≥20% (Standard Extract)
HPLC ≥98% (High-Purity Monomer, Research/Pharma Grade)

检测方法

HPLC, UV

HPLC, UV

CAS No.

6754-58-1

6754-58-1

分子式

C₂₁H₂₂O₅

C₂₁H₂₂O₅

分子量

354.40

354.40

溶解性

脂溶性极强，水溶性极差。
易溶于甲醇、乙醇、DMSO、氯仿、乙酸乙酯；几乎不溶于水。

Highly lipophilic, poorly water-soluble.
Soluble in methanol, ethanol, DMSO, chloroform, ethyl acetate; practically insoluble in water.

药理功效

1. 超强抗氧化与抗衰老 (Potent Antioxidant & Anti-aging)：激活Nrf2通路，清除自由基能力极强，是维生素C的15倍以上。抑制弹性蛋白酶，促进胶原蛋白合成，减少皱纹。
2. 抗炎与免疫调节 (Anti-inflammatory & Immunomodulation)：抑制NF-κB通路和COX-1/COX-2酶活性，有效减轻慢性炎症，调节肠道菌群。
3. 化学预防与抗癌 (Chemoprevention & Anti-cancer)：抑制癌细胞增殖，诱导癌细胞凋亡，阻断血管生成（抗血管生成），对乳腺癌、前列腺癌、结肠癌等有显著抑制作用。
4. 代谢调节 (Metabolic Regulation)：激活AMPK/SIRT1通路，改善胰岛素抵抗，降低血脂，辅助减肥。
5. 抗病毒 (Antiviral)：对HSV-1（单纯疱疹病毒）、CMV（巨细胞病毒）、BVDV（牛病毒性腹泻病毒）及流感病毒有抑制作用。

1. Potent Antioxidant & Anti-aging: Activates Nrf2 pathway, extremely strong free radical scavenging ability (15x stronger than Vitamin C). Inhibits elastase, promotes collagen synthesis, reduces wrinkles.
2. Anti-inflammatory & Immunomodulation: Inhibits NF-κB pathway and COX-1/COX-2 enzyme activity, effectively reduces chronic inflammation, modulates gut microbiota.
3. Chemoprevention & Anti-cancer: Inhibits cancer cell proliferation, induces apoptosis, blocks angiogenesis. Shows significant inhibitory effects on breast, prostate, and colon cancers.
4. Metabolic Regulation: Activates AMPK/SIRT1 pathway, improves insulin resistance, lowers blood lipids, aids in weight loss.
5. Antiviral: Inhibits HSV-1, CMV, BVDV, and influenza viruses.

应用领域

保健品/功能性食品：男性前列腺健康（核心应用）、抗衰老口服液、护肝解酒产品（啤酒花来源的天然解酒成分）、代谢综合征调理产品。
化妆品：顶级抗衰老精华（针对光老化和氧化损伤）、抗炎舒缓霜、祛痘产品（抑制痤疮杆菌）、美白淡斑产品（抑制酪氨酸酶）。
医药研发：抗癌辅助药物、抗病毒药物、抗纤维化药物的候选成分。
食品添加剂：天然抗氧化剂（用于富含油脂的食品保鲜，但成本较高）。

Health Products/Functional Food: Men's Prostate Health (core application), anti-aging oral liquids, liver protection and hangover relief products (natural hangover ingredient from hops), metabolic syndrome management products.
Cosmetics: Premium anti-aging serums (targeting photoaging and oxidative damage), anti-inflammatory soothing creams, acne products (inhibits P. acnes), whitening and spot removal products (inhibits tyrosinase).
Pharma R&D: Candidate for adjuvant anti-cancer drugs, antiviral drugs, and anti-fibrotic drugs.
Food Additive: Natural antioxidant (for preserving oily foods, but high cost).

包装储存

关键提示：本品极易氧化，且水溶性差，需注意配方增溶技术（如环糊精包合、纳米乳）。
包装：内双层铝箔袋充氮密封，外纸板桶（1kg/袋，25kg/桶）。
储存：密封，充氮或真空，避光，-20°C冷冻或2-8°C冷藏保存。保质期2年。

Critical Note: Highly prone to oxidation and poor water solubility. Solubilization techniques (e.g., cyclodextrin inclusion, nanoemulsion) are required for formulation.
Packaging: Inner double-layer aluminum foil bag with nitrogen filling, outer cardboard drum (1kg/bag, 25kg/drum).
Storage: Sealed, nitrogen-filled or vacuum, protected from light, stored at -20°C (freezer) or 2-8°C (refrigerator). Shelf life 2 years.