上海陌孚医药科技有限公司

一、产品基本信息

中文名称    :Resveratrol
中文别名    :白藜芦醇;芪三酚;3,4',5-三羟基芪;(E)-5-[2-(4-羟苯基)-乙烯基]-1,3-苯二酚;白黎芦醇;淫羊藿素;3,4,5-三羟基反式;(E)-3,5,4'-三羟基芪;反式白藜芦醇;Resveratrol 白藜芦醇;Resveratrol 白藜芦醇 标准品;白藜芦醇 EP标准品;白藜芦醇 Resveratrol;白藜芦醇 虎杖根提取物;白藜芦醇 虎杖提;白藜芦醇 葡萄皮提取物 热销;白藜芦醇（标准品）;白藜芦醇（合成）;白藜芦醇(虎杖提取物);白藜芦醇,Resveratrol,植物提取物,标准品,对照品;白藜芦醇,对照品;白藜芦醇.虎杖苷.薄荷醇.丹皮酚.丹酚酸A.丹酚酸B;白藜芦醇[虎杖提取物];白藜芦醇标准品;白藜芦醇--瑞树专利产品;虎杖甙元;虎杖提取物;虎杖提取物白藜芦醇;葡萄皮提取物;淫羊藿甙;3,4',5-三羟基二苯乙烯;3,4',5-三羟基茋;3,4‘,5-三羟基芪;trans-白藜芦醇,反式-白藜芦醇 标准品;白藜芦醇(芪三酚,3,4',5-三羟基芪,虎杖甙元);白藜芦醇.3,4',5-三羟基芪,虎杖甙元;反式-1,2-(3,4',5-三羟基二苯基)乙烯;分析对照品;培利替尼;芪三酚,3,4',5-三羟基芪,(E)-5-[2-(4-羟苯基)-乙烯基]-1,3-苯二酚;茋三酚;3,4′,5-三羟基-反式-二苯乙烯;5-[(1E)-2-(4-羟苯基)乙烯基]-1,3-苯二醇;白藜芦醇， 虎杖甙元
英文名称    :Resveratrol
英文别名    :Resveratrol;trans-3,4,5-Trihydroxystilbene;3,4',5-Trihydroxy-trans-stilbene;5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol;(E)-5-(4-Hydroxystyryl)benzene-1,3-diol;DB0045;Giant Knotweed Extract Trans-Resveratrol;RESVERATROL(P) PrintBack;trans-resveratrol;trans-Resveratrol (SRT-501, RM1812, CA1201, Resvida,Vineatrol 20M, (E)-Resveratrol);3',4,5'-trihydroxy-trans-stilbene;RESVERATROLE;RESVERTROL;trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene;trans-3,5,4'-trihydroxy-stilbene;Veratrum album L alcohol;3,4',5-Stilbenetriol;[ "3,4',5-Stilbenetriol", " 3,4',5-Trihydroxystilbene" ];3,4',5-Trihydroxystilbene;3,5,4'-Trihydroxystilbene;(E)-resveratrol;Resvida;5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol;SRT501;3,5,4'-Trihydroxy-trans-stilbene;Resveratol;5-[(E)-2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol;3,4',5-trihydroxy-stilbene;Resveratrol, natural;tran
Cas No.    :501-36-0
分子式    :C14H12O3
分子量    :228.24
包装储存    :Powder； -20°C； 3 years; 4°C； 2 years；

生物资料

生物活性    ：Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model. Resveratrol increases production of NO in endothelial cells.
性状    ：Solid
IC50 & Target[1][2]    
Adenylyl cyclase
0.8 nM (IC50)IKKβ
1 μM (
体外研究(In Vitro)    ：Resveratrol (trans-Resveratrol; SRT501) is one of the numerous polyphenolic compounds found in several vegetal sources In the vast majority of cases, Resveratrol displays inhibitory/activatory effects in the micromolar range, which is potentially attainable pharmacologically, although targets with affinities in the nanomolar range have also been reported.
MCF-7 cells are plated in DME-F12 medium supplemented with 5% FBS in the presence of increasing concentrations of Resveratrol. Control cells are treated with the same volume of vehicle only (0.1% ethanol). Resveratrol inhibits the growth of MCF-7 cells in a dose-dependent fashion. Addition of 10 μM Resveratrol results in an 82% inhibition of MCF-7 cell growth after 6 days while at 1 μM, only a 10% inhibition is observed. The cells treated with 10 μM Resveratrol have a doubling time of 60 hr whereas control cells doubled

体内研究(In Vivo)    ：The average tumor volume is reduced by treatment with Resveratrol (trans-Resveratrol; SRT501) at a dose of 50 mg/kg body weight (195.5±124.8 mm; P<0.05) or 100 mg/kg body weight (81.7±70.5 mm; P<0.001) compare with the vehicle-treated animals (315±94 mm). There is a good correlation between the tumor volume and the tumor mass.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件    ：Room temperature or refrigerated transport.
储存方式    ：Powder； -20°C； 3 years; 4°C； 2 years； 
结构分类    ：Phenols
                      Polypheno

二、产品特性
Resveratrol是一种天然多酚，具有广泛的生物活性和药理作用，主要包括：

抗氧化：能够清除自由基，保护细胞免受氧化损伤。
抗炎：通过抑制炎症介质的释放和炎症信号通路的激活，发挥抗炎作用。
保护心脏：可降低血液粘稠度，抑制血小板凝结，保持血液畅通，预防心血管疾病。
抗癌：具有抑制肿瘤细胞生长、诱导细胞凋亡的作用，可用于癌症的化学预防和治疗。
此外，Resveratrol还具有雌激素样作用，可用于治疗乳腺癌等疾病，并有助于延缓衰老。

三、科研应用

细胞实验：Resveratrol是腺苷酸环化酶和AMPK的活化剂，能够减少细胞炎症，抑制癌症细胞的生长并诱导细胞凋亡。
在MCF-7乳腺癌细胞实验中，Resveratrol以剂量依赖性方式抑制细胞生长，高浓度处理可显著抑制细胞增殖。

动物实验：在高热量饮食小鼠模型中，Resveratrol可改善小鼠的健康状况，提高存活率。
在卵巢癌移植瘤小鼠模型中，腹腔注射Resveratrol可抑制瘤体生长。

作用机制：Resveratrol的靶点广泛，如COX、SIRT1、mTOR、JAK、IKKβ等，通过调节这些靶点的活性发挥药理作用。
Resveratrol可上调内皮型一氧化氮合酶（eNOS）的表达，刺激eNOS酶活性，增加内皮细胞中一氧化氮（NO）的生成，从而改善血管功能。

Resveratrol（白藜芦醇）作为一种天然抗氧化剂和多功能药物分子，在科研和医学领域具有广泛的应用前景。其抗氧化、抗炎、保护心脏和抗癌等特性使其成为心脑血管疾病、癌症等慢性疾病防治的重要研究对象。通过细胞实验和动物实验，已经证实了Resveratrol的多种药理作用和潜在的临床应用价值。未来，随着对白藜芦醇作用机制的深入研究和新型药物制剂的开发，Resveratrol有望在更多领域发挥重要作用，为人类健康事业做出更大的贡献。

来源：https://www.med-life.cn/product/1254834.html