文章标题：Human papillomavirus type 16 E6 promotes cervical cancer proliferation by upregulating transketolase enzymatic activity through the activation of protein kinase B
影响因子：4.6
期刊：MOLECULAR CARCINOGENESIS
作者列表：Shiming Hao, Qingfei Meng, Huihui Sun, Xiangzhe Yang, Bin Liu, Yanghe Zhang, Honglan Zhou, Zhixiang Xu, Yishu Wang
发表时间：2023-11-21
DOI:10.1002/mc.23656
主要研究成果：Abstract
The expression of food-anticipatory activity （FAA） is induced by restricted feeding （RF）, ａnd its entrainment requires food-entrainable oscillators, the neuroanatomical basis of which is currently unclear. Although RF impacts various hormones, sex-related differences in FAA are unclear. ＇Here, we report significantly more food-anticipatory wheel-running activity in male than in female mice during RF. In parallel with the sex-related difference in FAA, male ａnd female mice display different food intake ａnd body weight in response to RF. Since gonadal hormones could be involved in the sex-specific difference in FAA, we compared sham ａnd gonadectomized male ａnd female wild-type mice. In gonadectomized mice, the sex difference in FAA was abolished, indicating a role for gonadal hormones in FAA. Further, plasma concentrations of the hormone ghrelin were higher in female than in male mice during ad libitum （AL） feeding, ａnd RF induced a temporal advance in its peak in both sexes. RF also shifted the expression peak of the circadian gene mPer1 in the hippocampus ａnd liver, although no sex difference was found in either the level or the cyclic phase of its expression. Per1Brdm1 mutant mice were still sexually dimorphic for FAA, but diminished FAA was noted in both male ａnd female Per2Brdm1 mutant mice. In summary, our results imply that gonadal hormones contribute to the sex difference in FAA, possibly through modulating ghrelin activity.
