长沙上禾生物 中英文简介 大黄酚 (Chrysophanol)

产品名称

大黄酚

Chrysophanol (Chrysophanic Acid)

化学名称

1,8-二羟基-3-甲基-9,10-蒽二酮

1,8-Dihydroxy-3-methyl-9,10-anthracenedione

植物来源

蓼科植物掌叶大黄 (Rheum palmatumL.)、何首乌 (Polygonum multiflorumThunb.)、豆科植物决明子 (Cassia obtusifoliaL.) 等。

Rheum palmatumL., Polygonum multiflorumThunb., Cassia obtusifoliaL., etc.

化学分类

羟基蒽醌衍生物

Hydroxyanthraquinone Derivative

外观性状

金黄色或橙黄色针状结晶或结晶性粉末。

Golden yellow or orange-yellow needle-like crystals or crystalline powder.

主要规格

高纯单体 (HPLC): ≥95.0%, ≥98.0%, ≥99.0%
大黄/何首乌标准化提取物:
- 大黄酚 1%, 2%, 5%, 10% (HPLC)
- 总游离蒽醌 5%, 10%, 20% (UV/HPLC)
- 结合型蒽醌 可定制 (UV/HPLC)
常规提取物: 5:1, 10:1 (TLC)

High Purity Monomer (HPLC): ≥95.0%, ≥98.0%, ≥99.0%
Rheum/Polygonum Standardized Extract:
- Chrysophanol 1%, 2%, 5%, 10% (HPLC)
- Total Free Anthraquinones 5%, 10%, 20% (UV/HPLC)
- Combined Anthraquinones Customizable (UV/HPLC)
Conventional Extract: 5:1, 10:1 (TLC)

检测方法

HPLC, LC-MS, UV, TLC

HPLC, LC-MS, UV, TLC

CAS No.

481-74-3

481-74-3

分子式

C₁₅H₁₀O₄

C₁₅H₁₀O₄

分子量

254.24

254.24

药理功效

1. 刺激性泻下 (核心传统功效)：在结肠内被细菌转化为大黄酸蒽酮，刺激肠蠕动，促进排便。
2. 抗菌、抗真菌、抗病毒：对金黄色葡萄球菌、大肠杆菌、多种皮肤癣菌、流感病毒等有抑制作用。
3. 抗炎：抑制炎症因子和通路。
4. 保肝利胆：促进胆汁分泌，抗肝损伤。
5. 利尿。
6. 抗肿瘤：诱导肿瘤细胞凋亡。
7. 神经保护：潜在抗阿尔茨海默病作用。

1. Stimulant Laxative (Core traditional function): Converted to rhein anthrone by colonic bacteria, stimulates peristalsis, promotes defecation.
2. Antibacterial, Antifungal, Antiviral: Inhibits Staphylococcus aureus, E. coli, various dermatophytes, influenza virus, etc.
3. Anti-inflammatory: Inhibits inflammatory factors and pathways.
4. Hepatoprotective & Choleretic: Promotes bile secretion, protects against liver injury.
5. Diuretic.
6. Antitumor: Induces tumor cell apoptosis.
7. Neuroprotective: Potential anti-Alzheimer's effect.

应用领域

医药/保健品: 泻下药/通便产品 (短期使用)、抗菌抗炎外用制剂、保肝利胆产品。
化妆品: 抗痘产品 (抗菌、抗炎)、去屑洗发水 (抗真菌)、部分功能性护肤品。
兽药/饲料添加剂: 畜禽通便、抗菌、提高消化功能。
染料工业: 天然染料。
科研: 泻下、抗菌、肝保护机制研究的工具化合物。

Pharmaceuticals/Health Products: Laxatives/bowel regulation products (short-term use), antibacterial and anti-inflammatory topical preparations, hepatoprotective and choleretic products.
Cosmetics: Acne treatment products (antibacterial, anti-inflammatory), anti-dandruff shampoo (antifungal), some functional skincare.
Veterinary/Feed Additive: Laxative, antibacterial, improves digestive function in livestock.
Dye Industry: Natural dye.
Research: Tool compound for studying laxative, antibacterial, and hepatoprotective mechanisms.

包装储存

密封，避光，阴凉干燥处。

Sealed, protected from light, stored in a cool, dry place.