Adipogen Life Sciences

System Vaccinology Analysis of Predictors and Mechanisms of Antibody Response

A major challenge in vaccinology is learning how to induce durable protective immunity. Protection against infection is generally thought to be mediated by antibodies that prevent infection of host cells.

A recent study published in the journal Nature Immunology and led by Prof. Pulendran (Stanford University) can be important for vaccinology research and suggests a role for platelets, produced from precursor cells called megakaryocytes, in modulating antibody response durability. Following vaccination, megakaryocytes/platelets promote the survival of plasma cells in the bone marrow through integrin β1 and β2 mediated cell-cell contact and production of the cytokines APRIL and MIF (macrophage migration inhibitory factor).

AdipoGen Life Sciences is a leader in APRIL and BAFF research field and offers recombinant proteins, ELISA Kits and blocking antibodies, including a potent human APRIL blocking antibody: anti-APRIL (human), mAb (blocking) (Mahya-1). 

- anti-APRIL (human), mAb (blocking) (Mahya-1) (preservative free) (Prod. No. AG-20B-0078PF)

- anti-APRIL (mouse), mAb (blocking) (Centotto-1) (preservative free) (Prod. No. AG-20B-0083PF)

- anti-BAFF (mouse), mAb (blocking) (Sandy-2) (preservative free) (Prod. No. AG-20B-0063PF)

- anti-April (mouse), mAb (rec.) (blocking) (Apry-1-1) (preservative free) (Prod. No. AG-27B-0001PF)

- APRIL (human) (multimeric) (rec.) (Prod. No. AG-40B-0017)

- APRIL (mouse) (multimeric) (rec.) (Prod. No. AG-40B-0089)

- BAFF, Soluble (human) (60-mer) (rec.) (highly active) (Prod. No. AG-40B-0112)

- BCMA (mouse):Fc (human) (rec.) (Prod. No. AG-40B-0076)

- APRIL (human) ELISA Kit (Prod. No. AG-45B-0012)

- BAFF, Soluble (human) ELISA Kit (hypersensitive) (Prod. No. AG-45B-0001)

- BAFF, Soluble (mouse) ELISA Kit (Prod. No. AG-45B-0033)

Other related reagents can be found on this landing page.

LIT:

System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans: M. Cortese, et al.; Nat. Immunol. 26, 116 (2025)