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发布人:武汉艾美捷科技有限公司
发布日期:2024/9/2 16:38:00
小鼠CD38是一种II型跨膜糖蛋白,是一种双功能外酶,能够将烟酰胺腺嘌呤二核苷酸(NAD+)分解为环状ADP核糖(cADPR),然后将cADPR水解为二磷酸腺苷(ADPR)。它在未免疫小鼠的外周B系细胞表面以高水平表达,在生发中心B细胞上以低密度表达。也有报道称,它在NK细胞、一部分外周T细胞和胸腺细胞亚群(主要是TCRαβ+、CD4+、CD8+)上以中等水平表达。小鼠CD38也由未免疫小鼠腹腔中的所有Mac-1+巨噬细胞表达,但不由未刺激的骨髓来源巨噬细胞表达。抗CD38单克隆抗体已被证明可以诱导B和T细胞增殖,保护B细胞免于凋亡,并抑制B淋巴细胞的生成。
艾美捷SouthernBiotech大鼠抗小鼠CD38-LE/AF(NIMR-5):
货号:1635-14
克隆:NIMR-5
亚型:大鼠(LOU) IgG2aκ
亚型对照:大鼠IgG2a-LE/AF (KLH/G2a-1-1)
特异性:小鼠CD38
其他名称:T10, ADP-核糖环化酶, 环ADP-核糖水解酶
免疫原:BCL1 质膜糖蛋白
结合物:LE/AF(低内毒素/无叠氮化物)
缓冲液配方:磷酸盐缓冲液,pH 7.4
克隆性:单克隆
浓度:0.5 毫克/毫升
体积:1.0 毫升
推荐储存:2-8°C;在无菌条件下操作
BALB/c小鼠脾细胞用大鼠抗小鼠CD38-BIOT(SB Cat.No。1635-08)和大鼠抗小鼠CD45R-PE(SBCat.No.1665-09),然后是链霉抗生物素-FITC(SB Cat.No.7100-02)。
SouthernBiotech大鼠抗小鼠CD38-LE/AF(NIMR-5)应用:
FC – Quality tested
IHC-FS – Reported in literature
IP – Reported in literature
ELISA – Reported in literature
Sep – Reported in literature
Activ – Reported in literature
Costim – Reported in literature
Stim – Reported in literature
Apop – Reported in literature
Drug Delivery – Reported in literature
Block – Reported in literature
SouthernBiotech大鼠抗小鼠CD38-LE/AF(NIMR-5)文献参考:
1. Santos-Argumedo L, Teixeira C, Preece G, Kirkham PA, Parkhouse RM. A B lymphocyte surface molecule mediating activation and protection from apoptosis via calcium channels. J Immunol. 1993;151:3119-30. (Immunogen, FC, IP, Activ, Stim)
2. Harada N, Santos-Argumedo L, Chang R, Grimaldi JC, Lund FE, Brannan CI, et al. Expression cloning of a cDNA encoding a novel murine B cell activation marker. Homology to human CD38. J Immunol. 1993;151:3111-18. (FC, IP)
3. Lund FE, Solvason NW, Cooke MP, Heath AW, Grimaldi JC, Parkhouse RM, et al. Signaling through murine CD38 is impaired in antigen receptor-unresponsive B cells. Eur J Immunol. 1995;25:1338-45. (FC, IP, Costim)
艾美捷科技是SouthernBiotech的中国代理商,为科研工作者提供优质的产品与服务。
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