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发布人：武汉佰乐博生物技术有限公司
发布日期:2024/8/20 13:59:56
世界卫生组织于2024年8月12日发布的报告指出，全球猴痘疫情仍在持续。截至2024年6月30日，116个国家/领土/地区共向WHO报告了99176例实验室确诊病例和208例死亡。猴痘疫情再次构成“国际关注的突发公共卫生事件”。
值得注意的是，Clade Ib型猴痘病毒主要通过性接触传播，主要感染成年人；而近期发现Clade Ia型猴痘病毒则主要影响儿童，并通过多种传播方式传播。
6月新增26个国家报告了934例新增病例和4例死亡。东非的四个新国家（布隆迪、肯尼亚、卢旺达和乌干达）首次报告了猴痘病例，这些国家的病例均为Ⅰ型猴痘病毒。此外，科特迪瓦正在经历与II型猴痘病毒相关的疫情，南非报告了另外两例确诊病例。
Fig 1.2022年1月1日至2024年6月30日世卫组织从官方公开来源报告或确认的mpox确诊病例的地理分布
猴痘：从非洲森林到全球舞台
猴痘病毒（Mpox virus，MPXV），与天花病毒一样同属于痘病毒科（Poxviridae）的正痘病毒属（Orthopoxvirus）。这种病毒的形态特征鲜明，呈现圆角砖形或卵圆形，大小在200至400纳米之间。猴痘病毒粒子由脂蛋白包膜包裹，内部包含两个蛋白质侧体，以及一个含有大量双链DNA的厚膜核心。
Fig 2. 猴痘病毒电镜和结构图
猴痘病毒的核心蛋白包括A29L、A35R、B6R、M1R、H3L等，这些蛋白质在病毒的复制、结构稳定性和与宿主细胞的相互作用中发挥关键作用。病毒的基因组为双链DNA结构，长度约为197kb，基因组末端包含一个相同但方向相反的末端反向重复序列。这一复杂的基因组编码了约190个开放阅读框（ORFs），其中4个位于独特的末端反向重复序列（Terminal Inverted Repeats，TIRs）中。这些重复序列在病毒的基因组稳定性、复制和转录调控中扮演重要角色。
Fig 3. 猴痘病毒基因组图示
自2022年以来，猴痘疫情在多个国家爆发，不仅局限于传统流行区域，而且在欧洲、美洲、亚洲和中东等地出现病例，这标志着猴痘传播模式的显著变化。截至2024年6月，全球已有116个国家/领土/地区报告了猴痘病例，其中非洲区域报告的病例数最多，其次是美洲和欧洲区域。值得注意的是，刚果民主共和国报告了最多的猴痘病例，而其他国家如美国、巴西、西班牙、法国、哥伦比亚、墨西哥、英国、秘鲁、德国和澳大利亚也有较高的病例数。
Fig 4. 2022年1月1日至2024年6月30日世卫组织地区向世卫组织报告的每月实验室确认的mpox病例汇总流行曲线
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作为法国AntibodySystem亚洲总代理商，佰乐博生物提供猴痘病毒（Mpox)相关的蛋白/抗体/试剂盒产品，AntibodySystem团队对猴痘病毒(Mpox virus，Mpox)和痘苗病毒(vaccinia virus,VACV)的基因序列进行深度探索并成功设计开发真核系统表达的猴痘病毒(Mpox virus，Mpox)系列核心蛋白A29L、A35R、B6R、M1R、E8L以及相关具有生物学活性的中和抗体产品，助力疫苗、药物、诊断试剂等不同方向的研究。
真核表达猴痘核心蛋白及相关中和抗体
Monkeypox virus/MPXV A29L
A29L是细胞内成熟病毒（IMV）表面包膜蛋白（与牛痘病毒VACV,A27L同源）。溶瘤痘苗病毒(VV)属于痘病毒科中一拥有192 kb双螺旋DNA遗传物质的病毒,会在细胞质中繁殖出具有鞘膜的病毒,进而感染其他不同种的哺乳动物细胞及个体.VV中的A27L基因能表达出一14 kDa大小的鞘膜蛋白,此蛋白能与细胞表面上的硫酸乙酰肝素（Heparan Sulfate）作用使病毒跟细胞结合并且可催化细胞融合。
·Monkeypox virus/MPXV A29L
Catalog No：EVV13401
Name:Recombinant Monkeypox virus/MPXV A29L Protein, C-His
Predicted molecular weight：15.33 kDa
Expression system: Mammalian
Protein length: Asp2-Glu110
Protein length: Asp2-Glu110
SDS PAGE Purity：90%
SDS PAGE for Recombinant Monkeypox virus/MPXV A29L Protein
·Anti-Monkeypox virus/MPXV A29L Antibody
Catalog No：RVV13401
Name：Anti-Monkeypox virus/MPXV A29L Antibody (SAA0286）
Host species：Mouse
Applications：ELISA ,Neutralization
Species reactivity: MPXV
Stock：In stock
Detects Monkeypox virus/MPXV A29L indirect ELISAs
Monkeypox virus/MPXV A35R
A35R是细胞内包膜病毒粒子（IEV）和细胞外包膜病毒粒子（EEV）的包膜成分，与脊索痘病毒A33R同源。痘苗病毒中的A33R在病毒粒子在细胞间的传播中起着至关重要的作用，是疫苗开发的重要靶点，也有研究表明A35R是猴痘病毒(Monkeypox virus，MPXV)血清学检测的潜在靶点。
·Recombinant Monkeypox virus/MPXV A35R Protein
Catalog No：EVV13101
Name:Recombinant Monkeypox virus/MPXV A35R Protein, C-His
Predicted molecular weight：16.65 kDa
Expression system: Mammalian
Protein length: Val57-Thr181
Stock：In stock
SDS PAGE Purity：90%
SDS PAGE for Recombinant Monkeypox virus/MPXV A35R Protein
·Anti-Monkeypox virus/MPXV A35R Antibody (SAA0287)
Catalog No：RVV13101
Name:Anti-Monkeypox virus/MPXV A35R Antibody (SAA0287)
Host species：Mouse
Applications：ELISA ,Neutralization
Species reactivity: MPXV
Stock：In stock
Detects Monkeypox virus/MPXV A35R indirect ELISAs.
Monkeypox virus/MPXV B6R
B6R是宿主范围蛋白，位于细胞外包膜病毒粒子（EEV）的膜上，与牛痘病毒补体控制蛋白B5同源，参与补体激活的负调节。研究表明B5依赖于与A33或A34的相互作用，以定位到细胞内包膜的位点，并能相互结合释放到细胞外病毒体的包膜中。B5对于有效生产感染性EV至关重要，A33，A34，B5三者复合物在ER退出以及三种糖蛋白正确定位到包裹的细胞内部位中起作用。
·Recombinant Monkeypox virus/MPXV B6R/SL-159 Protein
Catalog No：EVV13501
Name:Recombinant Monkeypox virus/MPXV B6R/SL-159 Protein, C-His
Predicted molecular weight：31.73 kDa
Expression system: Mammalian
Protein length: Thr20-His279
Stock：In stock
SDS PAGE Purity：90%
SDS PAGE for Recombinant Monkeypox virus/MPXV B6R/SL-159 Protein
Monkeypox virus/MPXV M1R
M1R与牛痘病毒L1蛋白同源，是一种在成熟IMV颗粒表面发现的跨膜蛋白。由L1R ORF编码，高度保守，参与病毒粒子组装，在病毒进入和成熟过程中发挥重要作用。L1是诱导低pH触发的细胞-细胞融合所必需的，且对牛痘病毒复制至关重要。
·Recombinant Monkeypox virus/MPXV M1R Protein
Catalog No：EVV13301
Name:Recombinant Monkeypox virus/MPXV M1R Protein, C-His
Predicted molecular weight：22.35 kDa
Expression system: Mammalian
Protein length: Gly2-Gly183
Stock：In stock
SDS PAGE Purity：90%
SDS PAGE for Recombinant Monkeypox virus/MPXV M1R Protein
·Anti-Monkeypox virus/MPXV M1R Antibody
Catalog No：RVV13301
Name:Anti-Monkeypox virus/MPXV M1R Antibody (SAA0283)
Host species：Mouse
Applications：ELISA , Neutralization
Species reactivity: MPXV
Stock：In stock
Detects Monkeypox virus/MPXV M1R indirect ELISAs.
Monkeypox virus/MPXV E8L
E8L是病毒入侵宿主细胞重要基因，在病毒入侵宿主完成复制的过程中作为MV的细胞表面结合蛋白与细胞表面的硫酸软骨素结合，以提供病毒粒子附着在靶细胞上。有研究表明利用siRNA技术能有效拮抗Monkeypox virus的A6R和E8L基因，由此构建siA6-a和si8 -d能破坏MPV复制。
·Recombinant Monkeypox virus/MPXV E8L Protein
Catalog No：EVV13201
Name:Recombinant Monkeypox virus/MPXV E8L Protein, C-His
Predicted molecular weight：22.35 kDa
Expression system: Mammalian
Protein length: Gly2-Gly183
Stock：In stock
SDS PAGE Purity：90%
SDS PAGE for Recombinant Monkeypox virus/MPXV E8L Protein
·Anti-Monkeypox virus/MPXV E8L Antibody
Catalog No：RVV13201
Name:Anti-Monkeypox virus/MPXV E8L Antibody (SAA0285)
Host species：Mouse
Applications：ELISA , Neutralization
Species reactivity: MPXV
Stock：In stock
Detects Monkeypox virus/MPXV E8L indirect ELISAs.
Monkeypox virus/MPXV H3L
H3L是一种324个AA长的糖基转移酶，位于病毒包膜上，在与宿主细胞的附着和随后的痘病毒进入中起关键作用。研究表明，天花疫苗诱导的抗体与H3蛋白结合，分化簇 (CD8)+ T细胞将H3L识别为抗原，表明其免疫学意义。
·Recombinant Monkeypox virus/MPXV H3L Protein
Catalog No：EVV12701
Name:Recombinant Monkeypox virus/MPXV H3L Protein, C-His
Predicted molecular weight：35.46 kDa
Expression system: Mammalian
Protein length: Ala2-Phe282
Stock：In stock
SDS PAGE Purity：90%
SDS PAGE for Recombinant Monkeypox virus/MPXV H3L Protein
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Protein
Catalog No.
Product Name
YVV12702
Recombinant MPXV H3L Protein, N-His
EVV12703
Recombinant Monkeypox virus (MPXV) H3L Protein, C-Fc
EVV12704
Recombinant MPXV H3L Protein, C-His
YVV17101
Recombinant MPOX A5L Protein, N-GST & C-His
YVV21901
Recombinant Monkeypox virus/MPXV A42R/Profilin Protein, N-His
YVV17401
Recombinant Monkeypox virus/MPXV B16R Protein, N-His
YVV17301
Recombinant Monkeypox virus/MPXV D6L Protein, N-His
EVV17201
Recombinant Monkeypox virus/MPXV C15L Protein, C-His
EVV17101
Recombinant Monkeypox virus/MPXV A5L Protein, C-His
YVV16401
Recombinant Monkeypox virus/MPXV I1L Protein, N-His
YVV16301
Recombinant Monkeypox virus/MPXV B21R Protein, N-His
YVV13102
Recombinant Monkeypox virus/MPXV A35R Protein, N-GST & C-His
YVV13402
Recombinant Monkeypox virus/MPXV A29L Protein, N-GST & C-His
YVV15001
Recombinant Monkeypox virus/MPXV A30L Protein, N-His
YVV14901
Recombinant Monkeypox virus/MPXV L1R Protein, N-His
EVV12501
Recombinant Monkeypox virus/MPXV HA/B2R Protein, C-His
YVV14801
Recombinant Monkeypox virus/MPXV F3L Protein, N-His
YVV13601
Recombinant Monkeypox virus/MPXV D14L Protein, N-His
YVV13701
Recombinant Monkeypox virus/MPXV A14L Protein, N-GST & C-His
YVV13501
Recombinant Monkeypox virus/MPXV B6R/SL-159 Protein, N-His
YVV13401
Recombinant Monkeypox virus/MPXV A29L Protein, N-His
YVV13301
Recombinant Monkeypox virus/MPXV M1R Protein, N-His
YVV13201
Recombinant Monkeypox virus/MPXV E8L Protein, N-His
YVV13101
Recombinant Monkeypox virus/MPXV A35R Protein, N-His
EVV13601
Recombinant Monkeypox virus/MPXV D14L Protein, C-His
EVV13501
Recombinant Monkeypox virus/MPXV B6R/SL-159 Protein, C-His
EVV13401
Recombinant Monkeypox virus/MPXV A29L Protein, C-His
EVV13301
Recombinant Monkeypox virus/MPXV M1R Protein, C-His
EVV13201
Recombinant Monkeypox virus/MPXV E8L Protein, C-His
EVV13101
Recombinant Monkeypox virus/MPXV A35R Protein, C-His
YVV13001
Recombinant Monkeypox virus/MPXV A27L Protein, N-His
YVV12901
Recombinant Monkeypox virus/MPXV A26L Protein, N-GST & C-His
YVV12801
Recombinant Monkeypox virus/MPXV C18L Protein, N-His
YVV12701
Recombinant Monkeypox virus/MPXV H3L Protein, N-His
YVV12601
Recombinant Monkeypox virus/MPXV A44R Protein, N-GST & C-His
YVV12501
Recombinant Monkeypox virus/MPXV B2R/Hemagglutinin Protein, N-His
YVV12401
Recombinant Monkeypox virus/MPXV D13L Protein, N-His
YVV12301
Recombinant Monkeypox virus/MPXV C19L Protein, N-His
YVV12201
Recombinant Monkeypox virus/MPXV A36R Protein, N-His
YVV12101
Recombinant Monkeypox virus/MPXV B5R Protein, N-His
YVV12001
Recombinant Monkeypox virus/MPXV A33R Protein, N-His
EVV13302
Recombinant MPXV M1R Protein, C-His
Antibody
Catalog No.
Product Name
RVV13502
Anti-MPXV B6R/SL-159 Antibody (SAA2204)
RVV13501
Anti-MPXV B6R/SL-159 Antibody (SAA2203)
MVV12703
Anti-MPXV H3L Monoclonal Antibody (1A436)
MVV12702
Anti-MPXV H3L Monoclonal Antibody (1A435)
MVV12701
Anti-MPXV H3L Monoclonal Antibody (1A434)
RVV13102
Anti-Monkeypox virus/MPXV A35R Antibody (SAA0287)
RVV13418
Anti-Monkeypox virus/MPXV A29L Antibody (SAA0286)
RVV13202
Anti-Monkeypox virus/MPXV E8L Antibody (SAA0285)
RVV13304
Anti-Monkeypox virus/MPXV M1R Antibody (SAA0284)
RVV13303
Anti-Monkeypox virus/MPXV M1R Antibody (SAA0283)
RVV12702
Anti-Monkeypox virus/MPXV H3L Antibody (SAA0282)
PVV21901
Anti-MPXV A42R/Profilin Polyclonal Antibody
MVV13403
Anti-MPXV A29L Antibody (1A005)
MVV13402
Anti-MPXV A29L Antibody (1A004)
MVV13401
Anti-MPXV A29L Antibody (1A003)
PVV16301
Anti-Monkeypox virus B21R Polyclonal Antibody
PVV17101
Anti-MPOX A5L Polyclonal Antibody
RVV13417
Anti-MPXV A29L Antibody (P2E12)
RVV13416
Anti-MPXV A29L Antibody (P2H9)
RVV13415
Anti-MPXV A29L Antibody (P2G9)
RVV13414
Anti-MPXV A29L Antibody (P2B8)
RVV13413
Anti-MPXV A29L Antibody (P2A6)
RVV13412
Anti-MPXV A29L Antibody (P2E5)
RVV13411
Anti-MPXV A29L Antibody (P2H3)
RVV13410
Anti-MPXV A29L Antibody (P2G3)
RVV13409
Anti-MPXV A29L Antibody (P1H10)
RVV13408
Anti-MPXV A29L Antibody (P1D7)
RVV13407
Anti-MPXV A29L Antibody (P1B7)
RVV13406
Anti-MPXV A29L Antibody (P1D4)
RVV13405
Anti-MPXV A29L Antibody (P1F2)
RVV13404
Anti-MPXV A29L Antibody (P1E2)
RVV13403
Anti-MPXV A29L Antibody (P1A2)
RVV13402
Anti-MPXV A29L Antibody (P1H1)
RVV13501
Anti-MPXV B6R/SL-159 Antibody (SAA2203)
RVV13502
Anti-MPXV B6R/SL-159 Antibody (SAA2204)
PVV17401
Anti-Monkeypox virus/MPXV B16R Polyclonal Antibody
PVV17301
Anti-Monkeypox virus/MPXV D6L Polyclonal Antibody
PVV16401
Anti-Monkeypox virus/MPXV I1L Polyclonal Antibody
PVV13401
Anti-Monkeypox virus/MPXV A29L Polyclonal Antibody
PVV13101
Anti-Monkeypox virus/MPXV A35R Polyclonal Antibody
PVV15001
Anti-Monkeypox virus/MPXV A30L Polyclonal Antibody
PVV14901
Anti-Monkeypox virus/MPXV L1R Polyclonal Antibody
PVV14801
Anti-Monkeypox virus/MPXV F3L Polyclonal Antibody
PVV13601
Anti-Monkeypox virus/MPXV D14L Polyclonal Antibody
PVV13701
Anti-Monkeypox virus/MPXV A14L Polyclonal Antibody
PVV13501
Anti-Monkeypox virus/MPXV B6R/SL-159 Polyclonal Antibody
PVV13301
Anti-Monkeypox virus/MPXV M1R Polyclonal Antibody
PVV13201
Anti-Monkeypox virus/MPXV E8L Polyclonal Antibody
PVV13001
Anti-Monkeypox virus/MPXV A27L Polyclonal Antibody
PVV12901
Anti-Monkeypox virus/MPXV A26L Polyclonal Antibody
PVV12801
Anti-Monkeypox virus/MPXV C18L Polyclonal Antibody
PVV12701
Anti-Monkeypox virus/MPXV H3L Polyclonal Antibody
PVV12601
Anti-Monkeypox virus/MPXV A44R Polyclonal Antibody
PVV12501
Anti-Monkeypox virus/MPXV B2R/HA/Hemagglutinin Polyclonal Antibody
PVV12401
Anti-Monkeypox virus/MPXV D13L Polyclonal Antibody
PVV12301
Anti-Monkeypox virus/MPXV C19L Polyclonal Antibody
PVV12201
Anti-Monkeypox virus/MPXV A36R Polyclonal Antibody
PVV12101
Anti-Monkeypox virus/MPXV B5R Polyclonal Antibody
PVV12001
Anti-Monkeypox virus/MPXV A33R Polyclonal Antibody
RVV13101
Mouse Anti-Monkeypox virus/MPXV A35R Antibody
RVV13401
Mouse Anti-Monkeypox virus/MPXV A29L Antibody
RVV13201
Mouse Anti-Monkeypox virus/MPXV E8L Antibody
RVV13302
Mouse Anti-Monkeypox virus/MPXV M1R Antibody
RVV13301
Mouse Anti-Monkeypox virus/MPXV M1R Antibody
RVV12701
Mouse Anti-Monkeypox virus/MPXV H3L Antibody
KIT
Catalog No.
Product Name
KAV13402
Anti-MPXV A29L Human IgG ELISA Kit
KAV13403
Anti-MPXV A29L Human IgM ELISA Kit
KAV13404
Anti-MPXV A29L Human IgA ELISA Kit
KAV13102
Anti-MPXV A35R Human IgG ELISA Kit
KAV13103
Anti-MPXV A35R Human IgM ELISA Kit
KAV13104
Anti-MPXV A35R Human IgA ELISA Kit
KAV13302
Anti-MPXV M1R Human IgG ELISA Kit
KAV13303
Anti-MPXV M1R Human IgM ELISA Kit
KAV13304
Anti-MPXV M1R Human IgA ELISA Kit
KAV13202
Anti-MPXV E8L Human IgG ELISA Kit
KAV13203
Anti-MPXV E8L Human IgM ELISA Kit
KAV13204
Anti-MPXV E8L Human IgA ELISA Kit
KAV12702
Anti-MPXV H3L Human IgG ELISA Kit
KVV13501
Monkeypox Virus (MPXV) B6R Antigen ELISA Kit
KVV13401
Monkeypox Virus (MPXV) A29L Antigen ELISA Kit
KVV13402
Monkeypox Virus (MPXV) A29L Antigen ELISA Kit-HS
KVV13101
Monkeypox Virus (MPXV) A35R Antigen ELISA Kit
KVV13301
Monkeypox Virus (MPXV) M1R Antigen ELISA Kit
KVV13201
Monkeypox Virus (MPXV) E8L Antigen ELISA Kit
KVV12701
Monkeypox Virus (MPXV) H3L Antigen ELISA Kit
参考文献：
[1]Subunit recombinant vaccine protects against monkeypox. J Immunol. 2006 Aug 15;177(4):2552-64. doi: 10.4049/jimmunol.177.4.2552
[2]Outbreak of human monkeypox in Nigeria in 2017-18: a clinical and epidemiological report. Lancet Infect Dis. 2019 Aug;19(8):872-879. doi: 10.1016/S1473-3099(19)30294-4
[3]A Nucleic Acid-Based Orthopoxvirus Vaccine Targeting the Vaccinia Virus L1, A27, B5, and A33 Proteins Protects Rabbits against Lethal Rabbitpox Virus Aerosol Challenge. J Virol. 2022 Feb 9;96(3):e0150421. doi: 10.1128/JVI.01504-21
[4]Mapping and functional analysis of interaction sites within the cytoplasmic domains of the vaccinia virus A33R and A36R envelope proteins. J Virol. 2003 Apr;77(7):4113-26. doi: 10.1128/jvi.77.7.4113-4126.2003
[5]Vaccinia virus induces cell fusion at acid pH and this activity is mediated by the N-terminus of the 14-kDa virus envelope protein. Virology. 1990 Sep;178(1):81-91. doi: 10.1016/0042-6822(90)90381-z
[6]Molecular Evidence of Human Monkeypox Virus Infection, Sierra Leone. Emerg Infect Dis. 2019 Jun;25(6):1220-1222. doi: 10.3201/eid2506.180296
[7]Inhibition of monkeypox virus replication by RNA interference. Virol J. 2009 Nov 4;6:188. doi: 10.1186/1743-422X-6-188
[8]Rapid protection in a monkeypox model by a single injection of a replication-deficient vaccinia virus. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10889-94. doi: 10.1073/pnas.0804985105
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