Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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8-Hydroxy-5-nitroquinoline(4008-48-4)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
8-Hydroxy-5-nitroquinoline
Synonyms
5-Nitro-8-hydroxyquinoline
5-Nitro-8-oxyquinoline
5-Nitro-8-quinolinol
5-Nitroquinolin-8-ol
Nitroxoline
Noxibiol
CAS
4008-48-4
Formula
C9H6N2O3
Molecular Weight
190.15
EINECS
223-662-4
RTECS
VC8225000
RTECS Class
Tumorigen
Merck
12,6753
Beilstein/Gmelin
166146
Beilstein Reference
5-21-03-00297

Physical and Chemical Properties

Appearance
Purple-yellow to brown powder.
Solubility in water
Very soluble
Melting Point
179 - 181
Boiling Point
419
Vapor Pressure
1E-7 (25 C)
Density
1.549 g/cm3 (22 C)
pKa/pKb
2.33 (pKa)
Partition Coefficient
2
Heat Of Vaporization
69.9 kJ/mol
Heat Of Combustion
-4283 kJ/mol
Usage
An antibiotic.

First Aid Measures

Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Ingestion
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Skin
May cause skin irritation.
Eyes
May cause eye irritation.

Exposure Controls/Personal Protection

Personal Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Fire Fighting Measures

Flash Point
207
Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Accidental Release Measures

Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Incompatibilities
Oxidizing agents.
Stability
Stable under normal temperatures and pressures.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
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