Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information
Home > 8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid > 8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid(313-67-7)

8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid(313-67-7)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information

Product Identification

Product Name
8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid
Synonyms
Aristolochic acid 1
Aristolochic acid A
Aristolochic acid I
Phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitro-
Tardolyt
TR 1736
CAS
313-67-7
Formula
C17H11NO7
Molecular Weight
341.27
EINECS
206-238-3
RTECS
CF3325000
RTECS Class
Tumorigen; Drug; Mutagen; Human Data; Natural Product
Merck
12,822
Beilstein/Gmelin
345159
Beilstein Reference
5-19-07-00611

Physical and Chemical Properties

Appearance
Orange-yellow powder.
Solubility in water
Slightly soluble
Density
1.499 g/cm3
pKa/pKb
3.18 (pKa)
Partition Coefficient
2.79
Usage
Contained in a number of botanical products sold as traditional medicines or as dietary supplements or weight-loss remedies. It’s use can cause permanent kidney damage and cancer.

First Aid Measures

Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked.
Handling
Wash thoroughly after handling. Wash hands before eating. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Inhalation
May cause respiratory tract irritation.
Skin
May cause skin irritation. Prolonged and/or repeated contact may cause irritation and/or dermatitis.
Eyes
May cause eye irritation.
Ingestion
Harmful if swallowed. May cause irritation of the digestive tract. May cause kidney damage. Human fatalities have been reported from acute poisoning.
UN (DOT)
1544

Exposure Controls/Personal Protection

Personal Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Exposure Effects
Prolonged or repeated skin contact may cause dermatitis. May cause kidney damage.
Poison Class
2

Fire Fighting Measures

Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire Potential
Non-Combustible

Accidental Release Measures

Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Incompatibilities
Oxidizing agents.
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Combustion Products
Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number
1544
Hazard Class
6.1
Packing Group
I; II; III
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