Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
Home > 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone > 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone(52-86-8)

4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone(52-86-8)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone
Synonyms
4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone
4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Aloperidin
Aloperidolo
Aloperidon
gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorbutyrophenone
CAS
52-86-8
Formula
C21H23ClFNO2
Molecular Weight
375.87
EINECS
200-155-6
RTECS
EU1575000
RTECS Class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,4629
Beilstein/Gmelin
331267
Beilstein Reference
5-21-02-00377

Physical and Chemical Properties

Appearance
Clear, colorless solution with no odor.
Solubility in water
14 mg/L
Melting Point
147
Boiling Point
529
Vapor Pressure
5E-12 (25 C)
Density
1.3 g/cm3 (20 C)
pKa/pKb
5.75 (pKb)
Partition Coefficient
3.36
Heat Of Vaporization
84.6 kJ/mol
Usage
Medication (vet).

First Aid Measures

Ingestion
Wash mouth out with water. Seek medical aid.
Inhalation
Remove to fresh air. Seek medical aid.
Skin
Flush skin with water. Seek medical aid.
Eyes
Flush eyes with water. Seek medical aid.

Handling and Storage

Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Exposure Controls/Personal Protection

Personal Protection
Latex gloves, safety goggles, disposable protective apparel.
Respirators
NIOSH approved respirator.
Exposure Effects
Abnormally low blood pressure may develop in adults and children who have ingested an overdose of haloperidol. One pediatric case of elevated blood pressure following overdose has been reported. Elevated body temperature has both been associated with haloperidol therapy and may occur with overdose. Respiratory depression may occur. haloperidol - severe extrapyramidal effects may follow overdose. Irreversible tardive dyskinesia has been reported with therapeutic use and may occur with overdose. Seizures have been reported with pediatric overdose. Neuroleptic malignant syndrome has been rarely reported in adults and children. Droperidol - extrapyramidal effects have been reported following droperidol therapy. Neuroleptic malignant syndrome has been reported in adults and children.

Fire Fighting Measures

Flash Point
274
Fire Fighting
Wear SCBA and protective clothing. Use extinguishing media most appropriate for surrounding fire.

Accidental Release Measures

Small spills/leaks
Wear recommended protective equipment. Sweep up material or absorb with paper towels. Place in appropriate container for disposal.

Stability and Reactivity

Stability
Stable at normal temperature and pressure.
Contact More